A Study Of Mechanism Of Anti-Nociceptive And Anti-Inflammatory Activity Of Ethanolic Extract Of Curcuma Longa In Invitro And Invivo Model

Abstract

Aim and Background: In the present study was investigate that the evaluate the Anti nociceptive and Anti-inflammatory activity of alcoholic extract of Curcuma longa in mice. Curcuma longa is a perennial herb distributed throughout tropical and subtropical regions of the world. It is widely cultivated in Asian countries, mainly in India and China. As turmeric powder it has been in continuous use for its flavouring, as a spice in both vegetarian and non-vegetarian food preparations and has digestive properties. Materials and Methods: The rhizomes of C.longa were collected from a traditional medicine shop. It was transferred immediately to the laboratory. The plant materials were shade dried for one week. After drying the plant materials were used for experiments. The shade dried plant material was powdered with the help of mixer grinder. The fine particles were separated and stored in a clean container. It was used for further analysis. Results: The alcoholic extract of C.longa on preliminary phytochemical screening revealed the presence of volatile oils, terpinolene, sugars, carbohydrates, phenols, resins and alkaloids. There was no significant alteration in autonomic or behavioral responses in the mice treated with the alcoholic extract of the C.longa. The C.longa extract produced statistically significant 54.12% and 78.59% inhibition of the neurogenic and inflammatory nociception by formalin induced paw licking response in the early and late phases respectively compared to vehicle treatment.  Conclusion: To conclude, the present study indicates the multifaceted action of anti nociceptive and anti-inflammatory activity of C.longa for therapeutic efficacy of pain and inflammation and confirms the traditional claims by standardized scientific methods of evaluation.