Evaluation Of Hypnotic-Like Behaviour Of Adenium Obesum (Desert Rose) In Experimental Mice

Abstract

Insomnia is characterized by problems falling asleep, staying asleep, or changing the rhythm of their sleep, and it can cause significant distress and impairments in day-to-day functioning. Previous studies indicates that hypnotic effect of Adenium obesum has been evaluated in descriptive way. Therefore, the present study was based on evaluation of hypnotic potential of Adenium Obesum in animal models. Flowers of Adenium obesum were collected from the UP-East region, and authenticated from the botanist at NRBI Lucknow region with ref. no. NBRI/2022/11/0234. The animal house, Shri Ramswaroop Memorial University, Barabanki (UP) provided Swiss mice of weighing 60-80g. All the mice were divided into 4 groups (n=6) i.e., group 1- mice were administered only normal saline, group 2- mice were administered diazepam (2mg/kg) orally, group 3- mice were administered ethanolic flower extract of Adenium obesum (EFAO) at dose of 80mg/kg orally and group 4- mice were administered ethanolic flower extract of Adenium obesum (EFAO) at dose of 120mg/kg orally. All the groups were treated daily, for 21 days. Various parameters were studies like thiopental sodium induced sleeping time, motor co-ordination, light/dark arena and locomotor activity were performed. In resulted that ethanolic flower extract of Adenium obesum is much significant in the preclinical treatment of insomnia. Its mechanism of action may involve blocking neurotransmitter release and promoting the breakdown of catecholamines. In conclusion, ethanolic flower extract of Adenium obesum is effective in alleviating sleeplessness and resetting the thoughts in order to induce slumber. However, more research into its mechanism of action is required for more informed drug selection across a wide range of mental health issues.