Synthesis, Metal Complexing Properties And Antifungal Activity Of Sulpha Drug Containing Ligand

Abstract

Sulphathiazole (ST), a drug on condensation with tetrahydrophthalic anhydride(THPA) yield a ligand, 6-((4-(N-(thiazol-2-yl) sulfamoyl) phenyl) carbamoyl) cyclohex-3-enecarboxylic acid (THPAST). Metal complexes of THPAST were synthesised with transition metal ions i.e. Cu²⁺, Co²⁺, Ni²⁺, Mn²⁺, and Zn²⁺.The synthesised ligands(THPAST) and its metal complexes were analysed by various parameters like elemental analysis, Spectral analysis and magnetic moments. All the samples were monitored against common fungi for their antifungal activity.