PARADOXICAL CORRELATION OF LIPIDS IN SUSPECTED UNTREATED RHEUMATOID ARTHRITIS PATIENTS OF UTTARAKHAND

Abstract

Introduction: Rheumatoid Arthritis is an autoimmune disorder with many co morbidities. The present study was conducted to establish the clinical correlation of lipids mainly TG and TC levels in untreated suspected RA patients with cardiovascular complications.  Out of 300 patients 48% males and 52% were females. Methods inflammatory markers related to RA i.e. C-reactive protein, Rheumatoid Arthritis Factor, Uric Acid, Erythrocyte Sedimentation Rate and Serum Lipids were analyzed. Results: 70 patients out of 300 were suspected with untreated RA .61 patients had variations in Lipid profile where 24 patients had increased TC and TG levels and 37 patients had lower TC and TG Levels. 67 patients were suspected of untreated RA along with variation in TG/TC concentrations. The males were found to be more affected with RA with risk of CVD in comparison to females. The mean (x̅) age at risk RA and CVD was 42.6 Years for total 300 cases in this study, (x̅) age for suspected untreated RA and Lower levels of TG/TC  (x̅) age was 38.043 years. The Pearson coefficient Correlation (r) amongst Patients with suspected untreated RA and patients with lower TG/TC was (r=0.879915) moderately higher than patients with suspected untreated RA and with higher TG/TC which was ( r= 0.7365),stating the clinical correlation and lipid paradox amongst RA and Lower Levels of lipids concluding that Lipids may have paradoxical associations with inflammatory markers of RA.Conclusion:The lower levels of lipids significantly in RA patients may be due to inflammations caused by Rheumatoid Arthritis leading to lower levels of lipids suggesting the treatment strategies for RA to be modified and implemented for patient’s better treatment.