Hepatoprotective Activity Of Commicarpus Chinensis Extract Against Paracetamol-Induced Hepatic Damage In Wistar Rats

Abstract

Commicarpus chinensis has been traditionally used in Indian medicine for the treatment of hepatitis, gonorrhoea, and diabetes, but its efficacy is uncertain. However, folklore has provided us with many effective plant-based therapies. So there are claims that Commicarpus chinensis (family: Nyctaginaceae) can be used to treat hepatic diseases. The current research examined the role of an alcoholic extract of Commicarpus chinensis. It significantly reduced the increase in serum aspartate amino transferase (AST), Alanine amino transferase (ALT), alkaline phosphatase (ALP), and total serum bilirubin (SB) caused by paracetamol, while increasing lipid peroxidation (LPO) and glutathione (GSH) activities in the liver. A histopathological examination of the liver was previously performed to supplement the evidence from the biochemical analysis. The revelation that Commicarpus chinensis has a significant protective effect against acute hepatotoxicity caused by acetaminophen.