Effect Of Cannabis Seeds Powder As A Dietary Supplementation On Hepatic Tissue And Functions In Male Rats

Abstract

Due to its high nutritional content and useful properties, hempseeds are currently gaining popularity with the revival of the cultivation of C. sativa L. plants (industrial hemp). Examining the impact of hempseeds as dietary supplements on liver tissue and functions is the aim of this study. In this study two groups of male albino rats were used. Each group was containing 5 rats. The first group was considered as control group and the second group was considered as the treatment group. The rats in treatment group were orally administrated with 20 mg/kg BW/day of powdered whole cannabis seeds for 15 days. total serum protein, globulin and albumin, cholesterol, triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL), serum liver enzymes such as alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was screened. And the liver histopathology was also examined. The level of liver enzymes was not significant in treatment group (P<0.05). Cholesterol, TG, LDL was significantly decreased in treatment group (p<0.05), but the change was not significant occurred in the level of HDL and VLDL. Serum total protein, globulin and albumin were significantly altered in treatment group (P<0.05). over all liver tissue was not affected using cannabis seeds at mentioned dosage for 15 days. accordingly, we can conclude that the used cannabis seeds have positive effect on liver functions and no evidence on liver tissue damages or injury.