Recent Advancement In Topical Delivery Methods For The Treatment Of Psoriasis

Abstract

An autoimmune, inflammatory skin condition that can be fatal is called psoriasis. T lymphocytes are the cause of this condition. Nowadays, methotrexate (MTX), cyclosporine (CsA), acitretin, dexamethasone, and salicylic acid are the medications most frequently used to treat psoriasis. Conventional formulations, however, limit the therapeutic efficacy of medications due to their poor absorptive capacity, variable drug release characteristics, poor potential for selective targeting, poor retention of drug molecules in target tissue, and unexpected skin reactions. Extreme disease-related factors like hyperkeratosis and irritation make this issue even more difficult. This review, which aims to provide better drug delivery carriers, stresses the therapeutic effectiveness of polymers and their capacity to transfer the medication into the epidermal membrane's deeper layer. The polymers are crucial from a structural and physiochemical standpoint because they serve as a vehicle for the drug.