Study Of Lipid Profile In Subclinical Hypothyroidism
Background- A prevalent issue that lowers life's capacity for function is hypothyroidism. Alterations in lipid levels brought on by hypothyroidism raise the risk of cardiovascular disease.
Objectives- To study whether there is any correlation between serum lipid levels and hypothyroidism (subclinical) in a rural population.
Methods- It was a cross-sectional study conducted for a period of 1 year in Department of Biochemistry in a tertiary medical college. Control group consisted of 100 similar age and sex persons taken from a population coming for whole-body health checkup scheme. Case group consisted of 100 patients with hypothyroidism (subclinical). The subjects were selected from department of medicine. TSH was calculated using the sandwich approach, and T3, T4, and FT4 levels by the competitive principle. SPSS was used for analysis.
Results- The study was female preponderance. The mean age of patients with hypothyroidism was 52.13 years and that of controls was 46.14 years (P = 0.48). The mean total cholesterol level in cases was 241.96mg/dl and that in controls was 164.27 mg/dl (0.01). The mean serum TG value in cases with hypothyroidism was 155.18 mg/dl whereas that in euthyroid controls was 95.79 mg/dl. This difference was not statistically significant (P = 0.07). Patients with hypothyroidism had a mean high-density lipoprotein (HDL) value of 49.6 mg/dl and euthyroid controls had 50.1 mg/dl. However, this was not found to be statistically significant (P 0.14). When group A was compared with group C, the former had higher total cholesterol levels, which were statistically significant (P = 0.01). Mean level of TG in subclinical hypothyroidism was 148.45 mg/dl, and that in control was 95.79 mg/dl. When group A was compared to group C, the former had higher level of TG, which was statistically significant with the P-value of 0.01.
Conclusion- There is association between subclinical with dyslipidemia. This might be a potential risk factor for coronary artery disease.