Formulation, Characterization And Evaluation Of Oral Dosage Form Of Itraconazole To Enhance Solubility

Abstract

In this present study solubility of antifungal Itraconazole drug was enhanced with solid dispersion by using PEG6000 and PVP K30 as a carrier in different ratios followed formation of a compressed tablet. Tablets were prepared by compression method and evaluation parameters were screened for drug content, disintegration hardness of tablet and dissolution rate. In vivo study was also performed for determination of drug absorption. Tablets prepared by solid dispersion have been better rate of solubility and dissolution.