Design Development And Characterization Of Chitosan Sodium Alginate Biodegradable Transdermal Hydrogel For The Controlled Delivery Of Curcumin

Abstract

A transdermal chitosan sodium alginate biodegradable polymer blend hydrogel (Cr-Ct-HL) has been exploited for enhancing the bio-therapeutic possessions of curcumin aiding lauric acid as the plasticizer. The Cr-Ct-HL was prepared by cold method using lauric acid in optimized concentration for the physiochemical and thermostable formulation. The Cr-Ct-HL showed varied range of tensile strength, thickness and absorptivity elaborating discrete optimized physiochemical behaviour. The optimized hydrogel was qualitative illustrated for scanning electron microscopy, rheology pattern, swelling and drug content analysis for the detailed description elaborating the formulation more stable and evenly dispersed. The spreadability and pH analysis showed slightly acidic pH range of hydrogel, further in vitro drug release studies showed about 80-85% curcumin release at slightly acidic pH (5&6) validating the significant curcumin release at skin pH. Overall the current study efficiently demonstrated the biocompatible controlled curcumin delivery opening novel avenue to biologically safe transdermal therapy.