Rp-Hplc Method For The Estimation Of Rizatriptan Benzoate Tablets


  • Kavitha Rajesh , Prasad Prakash Nandedkar , Laila Subra , Selvakumar S , Suraj Ramchandra Shinde , J. Anantha Lakshmi , Kotra Chandra sekhar Rangaiah , N Sriram




A simple reverse phase HPLC method was developed for the simultaneous determination of rizatriptan benzoate, in pharmaceutical dosage form. An Inertsil C8 (150 ´ 4.6 mm), 5µ column from Schimadzu in gradient mode, with mobile phases pH 3.0 Potassium dihydrogen phosphate buffer and methonal was used. The flow rate was 2.0 ml/min and effluent was monitored at 225 nm. The retention time was 6.21 min. As per ICH guide lines the method was validated over the range of 25–150 µg/mL for the analyte, and is accurate (average accuracies of three different concentrations ranged from 98.3 to 99.1% for rizatriptan Benzoate. The proposed method can be used as alternative method to the reported ones for the routine determination of selected drugs under the study in pharmaceutical dosage forms.



2022-12-31 — Updated on 2022-12-31




How to Cite

Rp-Hplc Method For The Estimation Of Rizatriptan Benzoate Tablets. (2022). Journal of Pharmaceutical Negative Results, 2158-2167. https://doi.org/10.47750/pnr.2022.13.S10.251