Rp-Hplc Method For The Estimation Of Rizatriptan Benzoate Tablets

Authors

  • Kavitha Rajesh , Prasad Prakash Nandedkar , Laila Subra , Selvakumar S , Suraj Ramchandra Shinde , J. Anantha Lakshmi , Kotra Chandra sekhar Rangaiah , N Sriram

DOI:

https://doi.org/10.47750/pnr.2022.13.S10.251

Abstract

A simple reverse phase HPLC method was developed for the simultaneous determination of rizatriptan benzoate, in pharmaceutical dosage form. An Inertsil C8 (150 ´ 4.6 mm), 5µ column from Schimadzu in gradient mode, with mobile phases pH 3.0 Potassium dihydrogen phosphate buffer and methonal was used. The flow rate was 2.0 ml/min and effluent was monitored at 225 nm. The retention time was 6.21 min. As per ICH guide lines the method was validated over the range of 25–150 µg/mL for the analyte, and is accurate (average accuracies of three different concentrations ranged from 98.3 to 99.1% for rizatriptan Benzoate. The proposed method can be used as alternative method to the reported ones for the routine determination of selected drugs under the study in pharmaceutical dosage forms.

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Published

2022-12-31 — Updated on 2022-12-31

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How to Cite

Rp-Hplc Method For The Estimation Of Rizatriptan Benzoate Tablets. (2022). Journal of Pharmaceutical Negative Results, 2158-2167. https://doi.org/10.47750/pnr.2022.13.S10.251