The Role Of Vitamin D In Polycystic Ovary Syndrome

Authors

  • Abeer Albiomy Khalifa, Reham Hassan ELazony, Malak Musa AL-klbash, Shaimaa ELsayed hadhoud

DOI:

https://doi.org/10.47750/pnr.2022.13.S10.244

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of reproductive age women and contributes to metabolic dysfunctions including insulin resistance (IR) and dyslipidemia. Vitamin D is a steroid hormone, which is involved in calcium metabolism and bone structure and has a potential role in the prevention of many illnesses, including cancers, autoimmune disorders, hypertension, diabetes, and obesity. Recently, it has been reported that vitamin D deficiency was a common complication of PCOS and vitamin D status was associated with reproductive ability, metabolic alterations, and mental health of PCOS patients. This review summarizes the advances between vitamin D status and the pathophysiological process of PCOS. Vitamin D level was negatively associated with serum androgen level. Vitamin D treatment could reduce serum androgen and anti-MüllerianHormone (AMH) levels, and decrease endometrial thickness, which resulted in improvement of menstrual cycle and folliculogenesis of PCOS patients. Moreover, vitamin D concentrations were negatively correlated with parameters of IR and body fat mass. Vitamin D supplementation has beneficial effects on IR and lipid metabolism. In addition, a positive of vitamin D on mental health of PCOS patients was proposed. Understanding the relationship between vitamin D status and the symptoms of PCOS patients is of great clinical significance to treat and prevent the progression of PCOS.

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Published

2022-12-31 — Updated on 2022-12-31

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Articles

How to Cite

The Role Of Vitamin D In Polycystic Ovary Syndrome. (2022). Journal of Pharmaceutical Negative Results, 2094-2110. https://doi.org/10.47750/pnr.2022.13.S10.244