Formulation And Invitro Characterization Of Agomelatin Nasal Gels Using Natural Polymers

Abstract

Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepaticfirst pass metabolism. AGM-loaded solid dispersions were formulated in the form of an in situgel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. Solid dispersions were formulated using natural carriers like Xanthan gum & guargum alone and with combinations. Based on the percentage yield and drug content containing Xanthan gum & guargum in 1:0.75 ratio shows 98.10%, so F8 formulation having agomelatin was selected for the formulation of nasal gel using gellan gum & locust bean gum in different concentrations, among all the formulated nasal gel preparations G5 containing gellan gum & locust bean gum in 1.25:0.25 ratio shows successful nasal gel formulation with all the desired gel characteristics  with gelling time, syringeability, pH, Viscousity, invitro mucoadhesion study and invitro diffusion studies. So G5 formulation containing gellan gum & locust bean gum in 1.25:0.25 ratio was considered as the optimized formulation.