Study The Effect Of Antimicrobial Activity Of Some Synthesize Noval Qunazolino- 2,4,6- Tri -Substituted -S-Triazine Derivatives

Abstract

Quinazoline and triazine belong to a desirable class of heterocyclic hydrocarbons. As a starting point for the synthesis of triazine, anthranilic acid and substituted anthranilic acid have been used to create a number of synthetic analogues of triazine and quinazolinone. On agar plates, all the produced compounds were screened for their ability to kill off bacteria and fungi using the Saboraud's medium and Nutrient Broth method, respectively. Five gram-positive bacteria, included Staphylococcus aureus, Staphylococcus faecalis, Bacillus substilis, P. vulgaris, and B. pumilus, and two gram-negative bacteria, including Escherichia coli and Proteus vulgaris, were present in the bacterial culture. Agar diffusion was used to create fungal cultures of Saccharomyces cerevisiae, A. nigeria, Candida albicans, and Rhizopus oryzae. Negative bacteria were treated with Ciprofloxacin,  and Gram positive bacteria Norfloxacin, Benzyl penicillin, and Clotrimazole was used as an antifungal. The synthetic compounds demonstrated considerable antibacterial and antifungal activity on level with the effects of synthesise compound. The most active of these produced chemicals was compound code A-1.