Preparation And In-Vitro Evaluation Of Aceclofenac Floating Matrix Tablets

Abstract

Floating drug delivery systems bounce in the stomach for a long time without retarding gastric emptying time in the stomach for a long time since their bulk density is lower that of gastric fluids. The goal of the current study was to create a floating drug delivery systems for the model drug aceclofenac and analyze several processing factors such as, in-vitro drug release studies. The drug is removed from the system slowly and at the desired rate while the body is bouncing on the contents of the stomach. These floating tablets, which are primarily designed to reduce lag time and release the drug up to 12 hours after preparation, may also increase the bioavailability of the drug if it is used to its maximum potential rather than being dosed excessively regularly. The study included formulation of floating tablets using polymer like HPMC K4M, sodium bicarbonate, cellulose acetate pthalate, polyvinyl pthalate, carbapol, xanthun-gum, guar-gum, microcrystalline cellulose as matrix foaming agents. The in-vitro drug release pattern of Aceclofenac tablet was fitted to different kinetic models like zero order, first order, Higuchi an  Korsmeyer-peppas moldels. The drug release kinetics was evaluated by using the linear regression method. The drug release pattern of these floating tablets of Aceclofenac was correlated well with first order model over a period of 4hrs with fickian diffusion.