Correlation Of Serum Uric Acid With Lipid Profile And Platelet Counts In Gestational Hypertension Patients: Case-Control Study

Abstract

Introduction

An important global health problem for women and their offspring is hypertensive disorders of pregnancy (HDP). The most frequent medical issue during pregnancy is hypertension, which complicates 2-3% of pregnancies. According to this study, pregnant women with pregnancy- induced hypertension have lipid abnormalities, elevated levels of systemic inflammatory markers, and hyperuricemia compared to pregnant women without hypertension. Women with PIH who have high levels of inflammation, hyperuricemia, and dyslipidemia are therefore more likely to develop hypertension.Therefore, assessing these potential biomarkers during early antenatal care services may aid in the development of PIH interventions. 

Aim: To analyze the relation of serum uric acid with lipid profile and platelet counts in Gestational hypertension patients

Materials and Methods:

The case control study was conducted in which 93 subjects were recruited randomly. There were 31 pregnant women with hypertension called as study group and 62 pregnant women without hypertension as control. Results were statistically analyzed by Bi-Variate analysis to know the association between dependent and independent variable, chi-square was applied accordingly. A pregnant women having an average reading of systolic blood pressure (SBP) of more than/equal to 140 mmHg and/or diastolic blood pressure (DBP) of more than/equal to 90 mmHg was considered as hypertensive (DBP ≥90 mmHg and/or SBP ≥140 mmHg). In this study, we have evaluated lipid profile, uric acid and their relation with platelets in hypertensive pregnant women and same in non hypertensive pregnant women.

Results: BMI and systolic and diastolic blood pressure were markedly higher  (23.93 Kg/m²,161.35 mmHg,109.22 mmHg) in the hypertensive  than normotensive ones (22.73 Kg/m² ,115 mmHg,76.7 mmHg) The case group showed higher significance (p<0.05) in total cholesterol mg/dL (171.51±25.49 vs 207.74±31.94), HDL mg/dL (45.45±4.07 vs 43.93±2.92), LDL mg/dL (93.05±16.77vs133.42±34.20), VLDL mg/dL (30.27±7.83vs39.28±5.85) and TGL mg/dL (156.06±38.43vs196.41±29.29). In this study, we also discovered that pregnant women with hypertension had considerably higher uric acid levels than pregnant women with normotension. Additionally, we discovered that hypertensive women's platelet counts were lower.

Conclusion:

Based on our findings, we came to the conclusion that serum uric acid was significantly associated with a higher frequency of complications, and the subjects studied also had abnormal lipid profiles. Early detection of it will help in better management, and thus abating complications both for the mother and the fetus. We advise a more extensive investigation into platelet counts in both normal and hypertensive pregnant women.