“Recognition of New Antimicrobial Targets with Novel Benzaaldehyde containing O-alkyl chains”
There is an essential need to develop novel antibacterial agents against new bacterial targets in order to avoid the problem of cross-resistance. Almost in every bacterium topoisomerase IA is present, so that the enzyme activity is available to resolve topological blocks involving DNA single strands. It is a reasonable route to look for novel antibiotics by trying to develop small molecules that can trap the covalent complex formed by bacterial type IA topoisomerases. Bacterial topoisomerase is a target for development of novel antimicrobials because it has an important role in the transcription events. Thus topoisomerases are the potent drug targets due to their bactericidal effect.