“Recognition of New Antimicrobial Targets with Novel Benzaaldehyde containing O-alkyl chains”
DOI:
https://doi.org/10.47750/pnr.2022.13.S10.124Abstract
There is an essential need to develop novel antibacterial agents against new bacterial targets in order to avoid the problem of cross-resistance. Almost in every bacterium topoisomerase IA is present, so that the enzyme activity is available to resolve topological blocks involving DNA single strands. It is a reasonable route to look for novel antibiotics by trying to develop small molecules that can trap the covalent complex formed by bacterial type IA topoisomerases. Bacterial topoisomerase is a target for development of novel antimicrobials because it has an important role in the transcription events. Thus topoisomerases are the potent drug targets due to their bactericidal effect.
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2022-12-31 — Updated on 2022-12-31
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“Recognition of New Antimicrobial Targets with Novel Benzaaldehyde containing O-alkyl chains”. (2022). Journal of Pharmaceutical Negative Results, 1064-1075. https://doi.org/10.47750/pnr.2022.13.S10.124