Comparison of the efficacy of medical and surgical treatments in oral sub- mucous fibrosis cases: An original research

Authors

  • Dr. Yogiraj Babasaheb Virkar, Dr. Keshini MP, Dr. Syed Shah Hussain Qadri, Dr. Tharini Satheesh, Dr. Kedar Nath Nayak, Dr. Dayanithi B.S

DOI:

https://doi.org/10.47750/pnr.2022.13.S10.096

Abstract

Aim: Purpose of the present research was to assess the efficiency of different treatment modalities for oral submucous fibrosis.

Methodology: Eighty patients were included in the study, which was diagnosed as stage II oral submucous fibrosis (OSMF) based on habitual history and clinical findings. Four groups were made after randomization, i.e., group 1: capsule lycopene group, group 2: capsule lycopene and injection dexamethasone, group 3: injection dexamethasone and hyal¬uronidase group, Group 4: surgical treatment with split skin graft. Symptom severity was done by visual analog scale (VAS) scoring system viz burning sensation/pain in the patients; patient satisfaction was assessed. Vernier callipers were used to measure patients’ maximum mouth opening at day 1, 1st month, 2nd month, 3rd month.

Results: Male and female had the mean age of 28.20 ± 4.26 and 39.34 ± 2.12 in group 1, in group 2 was 27.88 ± 7.12 and 40.92 ± 7.16, in group 3 was 28.90 ± 8.69 and 40.10 ± 6.22 and group 4 was 29.3 ± 7.9, respectively. There was no statistically significant difference between treatment modalities based on satisfaction. On 2nd month, maximum patients with no pain were more in group 3 followed by group 2, and this was statistically significant and maximum pain was in group 4, however with no post operative infections were seen at surgical site. At a 3rd month, the maximum reduction in pain was in group 3 fol-lowed by group 2 and group 1. Mouth opening was improved in the group 3 followed by groups 2 and 1, respectively but was significantly improved in group 4. On 3rd month statistically significant difference was observed between the study groups.

Conclusion: The present study concludes that the treatment with dexamethasone + hyaluronidase group showed better results in improvement in mouth opening in OSMF patients than lycopene, lycopene and dexamethasone groups but surgical treatment was better with recurrence.

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Published

2022-12-31 — Updated on 2022-12-31

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How to Cite

Comparison of the efficacy of medical and surgical treatments in oral sub- mucous fibrosis cases: An original research . (2022). Journal of Pharmaceutical Negative Results, 868-872. https://doi.org/10.47750/pnr.2022.13.S10.096