Molecular Docking Studies Of Solanum Xanthocarpum Against Streptococcus Mutans In Dental Caries
Dental caries is one of the prevalent persistent disease conditions in humans. It is caused by the bacteria Streptococcus mutans, a major pathogen which when infected, creates an acidic environment in the mouth leading to the formation of biofilm thereby ends up in tooth decay. Dental caries can be managed by oral hygiene practices, fluoride application, pit and fissure sealants as the primary treatments today with temporary solution. But, Siddha medicine is emerging in treating the Dental caries which remains as the mainstay after all these years for the large population. In this study, Solanum xanthocarpum is identified as the Siddha form of medicine which consists of phytochemicals such as Carpesterol, Oleic acid, Solasodine, Diosgenin, Lupeol, Apigenin, Tomatidenol, Caffeic acid, Scopoletin that interacts with the binding site of target Glucosyltransferase (GFT) – PDB – 3AIC core amino acid residues (Asp588, Gln960, Glu515 and Asp477)of the S. mutans, binds with them and inhibit the synthesis of Extracellular polysaccharides through which the biofilm formation is suspended. The docking studies were carried out using identified phytocomponents against GFT proving the binding efficiency with all 4 amino acid residues by Carpesterol, Oleic acid, Solasodine followed by Diosgenin, Lupeol, Tomatidenol, Caffeic acid, Scopoletin bound with 3 amino acid residues.