Effect of Intravenous Injection of Aminophylline on Rapid Reduction of Headache Caused by Spinal Anesthesia

Abstract

Introduction: Post-Dural puncture headache (PDPH) is one of the most common and important complications after spinal anesthesia and lumbar puncture. This study aimed to determine the effect of intravenous injection of aminophylline on rapid relief headache caused by spinal anesthesia.
Materials and Methods: This was a clinical trial conducted on the cesarean section candidates referred to Razi Hospital of Torbat Heydariyeh and Bohlool Hospital of Gonabad affiliated to Gonabad University of Medical Sciences, Gonabad, Iran between 2018 and 2020. Sixty individuals were selected accessibly and purposefully in terms of the inclination criteria and were then randomly assigned into two groups (using the permutation block method). Group A received 3 mg/kg aminophylline plus 500 cc normal saline, and group B received 500 cc normal saline, infused over two hours. The severity of the headache was examined one to two hours after the infusion using a Visual Analogue Scale. Data were analyzed using SPSS version 21.
Results: The mean score of headache one hour after the infusion in group A (2.04 ± 1.80) was significantly lower than group B (7.1 ± 3.88) (p <0.001). The mean score of headache two hours after the infusion in group A (0.36 ± 0.08) was significantly lower than group B (6.62 ± 2.02) (p <0.001).
Conclusion: This study showed that intravenous injection aminophylline had significant efficacy in PDPH treatment.