Clinicopathological Study Of Gestational Trophoblastic Diseases

Abstract

Background: Gestational trophoblastic disease covers a wide spectrum of benign and malignant conditions that arise from pregnancies.

Materials and method: This was a prospective study conducted in the department of

Obstetrics and Gynaecology. Evaluation of all the patients with gestational trophoblastic diseases were done and their histological and clinical profile were recorded.

Conclusion: A simple beta-hCG test and early pregnancy USG may help in early recognition of abnormal pregnancy like gestational trophoblastic disease. In the present study early diagnosis and management has proved to decrease in mortality and serious morbidity successfully.

Keywords: beta-hCG, gestational trophoblastic disease, USGfeatures such as hypertension, edema, proteinuria, eclamptic condition, hyper thyroidism features like tachycardia and tremor, bleeding per vaginum, expulsion of moles, respiratory difficulty and features of liver dysfunction were taken. Inspection and per speculum examination was performed to access the height of uterus and adenexal pathology. Routine investigations were performed for each patient. Serum beta hCG serial estimation of serum beta HCG and time taken for the serum beta hCG to normalize to <5 mIU/dl was noted. USG, chest X ray and CT brain was performed in patients with pulmonary and neurological symptoms. In all cases of hydatidiform mole, suction evacuation was done and the product of conception were sent for histopathological examination.After evacuation of molar pregnancy following signs and symptoms were looked for like amenorrhoea, uterine enlargement, irregular vaginal bleeding, abdominal swelling, breathing