EFFECTIVENESS OF VIRGIN COCONUT OIL IN PERIODONTAL TREATMENT VIA ANALYSIS OF IL-1β AND IL-6

Authors

  • Hasanuddin Thahir , Arni Irawawaty Djais , Mansjur Nasir , Rachmi Bachtiar , Alfrida Pasangallo , Hatimurni , Harun Achmad

DOI:

https://doi.org/10.47750/pnr.2023.14.S01.12

Abstract

Background: Virgin Coconut Oil (VCO) is a vegetable oil extracted from coconut fleshcontains unsaturated fatty acids in the form of oleic acid and linoleic acid and flavonoids which function as anti-inflammatory. Periodontitis is an inflammatory disease of the periodontal tissues with a high prevalence worldwide. The main etiology of plaque periodontitis is biofilm containing colonies of pathogenic microorganisms. The occurrence of inflammation in the periodontal tissue stimulates the release of inflammatory mediators such as Interleukin-1β (IL-1β) and Interleukin-6 (IL-6). Treatment of periodontitis started from initial therapy, and usually accompanied by additional therapy such as local drug administration. VCO can be used as an alternative anti-inflammatory. Objectives is to determine the effect of VCO as a local drug delivery in periodontal treatment through analysis of IL-1β and IL-6. Methods: This is an experimental laboratory with a posttest-only control group design. VCO is made from grated fresh coconut and then mixed with NaCMC to get the consistency of the gel. The subjects of this study were 24 male Wistar rats that were induced by periodontitis by injecting Porphyromonas Gingivalis (P. Gingivalis) into the gingival sulcus. Wistar rats were then divided into 3 groups. On the 7th and 14th day, the rats were sacrificed and jaw samples were taken to determine the amount of IL-1β and IL-6 in the regenerative process of the periodontal tissue. Results: The amount of IL-1β and IL-6 decreased in all treatment groups, but not as big as the decrease in the VCO group. Conclusion:  VCO can reduce the amount of IL-1β and IL-6 in the treatment of wistar rats periodontal tissue induced by P. gingivalis.

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Published

2023-01-01 — Updated on 2023-01-01

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How to Cite

EFFECTIVENESS OF VIRGIN COCONUT OIL IN PERIODONTAL TREATMENT VIA ANALYSIS OF IL-1β AND IL-6. (2023). Journal of Pharmaceutical Negative Results, 113-122. https://doi.org/10.47750/pnr.2023.14.S01.12