Risk And Correlation Assessment Of Bone Mineral Density Changes In Inflammatory Bowel Disease Patients

Abstract

Background/purpose: Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD) thus, the aim of this study was to evaluate risk and correlation assessment of bone mineral density (BMD) changes in inflammatory bowel disease patients.

Patients and methods: The present study was a cross sectional study conducted at Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine in Menoufia University on 40 patients diagnosed as IBD (16 patients with crohn's disease and 24 patients with ulcerative colitis disease) and a control group consisted of twenty (20) apparent healthy persons. All patients and apparent healthy persons in the study were subjected to verbal consent, full history taking, physical examination, laboratory investigation, radiological investigations, bone mineral density (BMD) measurement.

Results: Among IBD patients, Crohn's disease patients had significantly more clinically active disease and they were with younger age at the disease diagnosis than the ulcerative colitis patients. Also, Crohn's disease patients had more significant past history of intestinal and colonic surgery. IBD patients were had significantly lower mean values of BMD (–T score) than the control group. BMD (T-score) is an excellent marker in predicting IBD patients from the apparent healthy control group with cutoff point >-0.375 with sensitivity 95% and specificity 90% and area under the curve 98%. In IBD patients, higher prevalence of osteoporosis was significantly more among older age patients and those with previous resection surgery.

Conclusion: BMD (T-score) is an excellent marker in predicting IBD patients. Also, there was an association between osteoporosis and older age patients and those with previous resection surgery.