Synthesis, Antimicrobial And Antioxidant Potential Of 2-(Substitutedphenyl)-3-(5-(Furan-2-Yl)-1,3,4-Oxadiazol-2-Yl) Thiazolidin-4-One Conjugates

Abstract

Background: A series of novel 5-(furan-2-yl)-1,3,4-oxadiazole analogues was prepared based on the abundant biological potential of the 1,3,4-oxadiazole moiety. A variety of spectral methods (1H-NMR, IR, MS, etc.) were used to confirm the chemical structures of the synthesized analogues. Antioxidant and antimicrobial activities of these synthesized compounds were assessed after they were prepared

Results and discussion: A serial tube dilution method was used to screen against selected strains of fungi and bacteria for antimicrobial activity in comparison with amoxicillin and fluconazole. The antioxidant potential of 5-(furan-2-yl)-1,3,4-oxadiazole compounds was assessed using the stable 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.

Conclusion: The antimicrobial screening results suggested that the synthesized derivatives 2,4,6,8, and 12 possessed moderate to promising potential against the selected species of microbial strains having MIC range 7.96 µM-9.97 µM. Structure activity relationship studies revealed compounds 2, 6 with p-bromo, trifluoro and 8 with p-chloro, substitutions were shown to be the most active among all the derivatives against the selected microbes. Compounds 2,4,6,8,9 and 12 were found to be more potent than the standard drug (ascorbic acid) in antioxidant evaluation assays. Among all the, compound 9 showed the highest antioxidant activity with an IC₅₀ of 18.56 µg/mL, compared to 23.22 µg/mL of standard drug.