Development and Characterization of Microwave Irradiated Solid Dispersion Lipid Nanoparticles Containing Topical Gel for Dermatophytosis
Keywords:Griseofulvin, Microwave Irradiation, Solid dispersions, Topical gel, PEG 6000, Carbopol – 940.
Background: The current study was designed to evaluate the enhancement of the antifungal activity of microwave irradiated solid dispersion-loaded local griseofulvin micro-gel containing the hydrophilic inactive carrier PEG-6000 formed by microwave irradiation against microbial strain. Microwave irradiated solid dispersion was characterized using Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM), and solubility were determined and the results showed that a 1: 4 ratio of drug to polymer gave better solubility. This can be due to the formation of an amorphous drug dispersion. The solid dispersion was then dispersed in gelling agent Carbopol 940 (CP-940) in the optimized concentration of 1.5% w / v. The gel thus formed was then analyzed and found to have all properties within a predetermined range at pH 7.5 and diffusivity of 7.86 gcm / s. In the texture analysis study, the hardness was 102.8 g and the adhesive strength was 100 ± 0.5 N / mm². In antifungal activity against microbial strain T. rubrum, the inhibition zone (ZOI) of the microgel and the marketed formulation was observed 25.4 mm and 14.1 mm, respectively when compared with the commercially available formulation. Griseofulvin's microwave irradiated solid dispersion was successfully formulated and showed enhanced solubility with effective antifungal activity.