In-silico study of functionality and co-relation of Capsaicin with TRPV1 in breast cancer cells

Authors

  • Tabinda Hasan
  • Kavitha Ganesh
  • Mary Antony Praba
  • Venkataramaniah

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.287

Keywords:

Transient receptor potential (TRP) channels, Apoptosis, Necrosis, Capsaicin.

Abstract

Background: In the last few years several studies have begun to elucidate and examine the expression of human Transient receptor potential (TRP) channels in breast cancer on large scale. TRP channels regulate intracellular calcium level, which promotes cancer. In many cases it plays an important role in dysfunctional gene transcription and in calcium- dependent pro-proliferative or anti-apoptotic pathways.
Aim: This in-silico study ascertained the functionality and co-relation of Capsaicin with TRPV1, a non-selective cation channel that is found to be expressed in different carcinoma tissues.
Methods: In this study, we performed molecular docking of TRPV1 with capsaicin and focussed on the hydrogen bonding which affects membrane transport, as well as the distribution of drugs within the biological system, binding energy and other factors like activation of TRPV1 by capsaicin.
Results: Activation of TRPV1 by caused substantial reticence of cancer growth. Capsaicin with TRPV1causedinduction of apoptosis, necrosis and significant inhibition of cancer cell growth.
Conclusion: TRPV1 orchestrates cell-micro environment crosstalk influencing cell behaviour. We concluded that activation of TRPV1 by capsaicin was associated with anti- cancer effects. Therefore, TRPV1 activation by Capsaicin presents a promising anticancer drug delivery system.

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Published

2022-11-23

How to Cite

Tabinda Hasan, Kavitha Ganesh, Mary Antony Praba, & Venkataramaniah. (2022). In-silico study of functionality and co-relation of Capsaicin with TRPV1 in breast cancer cells. Journal of Pharmaceutical Negative Results, 2419–2432. https://doi.org/10.47750/pnr.2022.13.S09.287

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