Recording the Body Weight Alterations in Hypothyroid Obese Mice Following Treatment with Alcoholic Extract of Citrullus Colocynthis
Keywords:Body weight, Hypothyroidism, Obesity, Alteration, Methimazole, Swiss albino mice.
Introduction: Hypothyroidism is marked by increased levels of TSH and decreased levels of T3 and T4. Hypothyroidism reduces the BMR leading to slowed down metabolism which is a result of imbalance in calorie consumption which leads to weight gain resulting in hypothyroid obesity.
Materials and Methods: Alteration in mice body weights were recorded after administering them Methimazole for 21 days then for the next 21 days group 3 and 4 were administered standard and the extract respectively, and rest both the groups were administered normal food and water. The mice were sacrificed at the end of the experiment and their liver was dissected out and histopathological studies were done on it to study the hypothyroid obesity linked changes in it.
Results: The alterations in body weight of the mice were found out by finding the difference between final and initial body weights, and the weight alterations were recorded to be significant. Histological studies revealed the appearance of fatty vacuoles throughout the liver in the disease group which had almost disappeared in the extract group.
Conclusion: The experiment lead to the conclusion that the body weight of the experimental mice had increased due to induction of hypothyroid obesity and the extract was effective in treating it and decreasing the mice body weight. The histological studies revealed the appearance of fatty vacuoles throughout the liver in the disease group and the extract was able to reverse these changes successfully to a great extent.