RESULTS OF TREATMENT OF PATIENTS WITH BLEEDING OF THE STOMACH AND 12 DUO FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS - INDUCED OENP

Authors

  • Urokov Sh. T
  • Khamroev B.S
  • Hamroyev Kh.N

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.228

Abstract

Analysis of the treatment results in patients with gastrointestinal bleeding with the use of endoscopic and surgical methods of hemostasis. The cause of bleeding can also be medical ulcers and erosions, which are localized in any part of the gastrointestinal tract. From 42% to 60% of patients indicated prior gastrointestinal bleeding aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants, antiplatelet agents. Some patients took 3 drugs per day: antiplatelet agents, anticoagulants and non-steroidal anti-inflammatory drugs . Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most popular classes of drugs.
Methods. Analysis of the treatment results in 275 patients with acute gastrointestinal bleeding from the urgent surgical department of Bukhara branch of the Republican cientific Center for Emergency Medical Care
Results. The patients were divided into groups II. The first group was studied retrospectively by studying 130 medical histories of patients with bleeding from NSAIDs induced by OEJP, who took traditional conservative treatment (hemostatics, angioprotectors, PPIs, H2-blockers, antacids) and underwent endoscopic diathermocoagulation. The second group conducted a prospective study, which included 145 patients of the main group taking drugs (traditional + omeprazole 20 mg + rebamipide 300 mg intravenously (slow drip) in 0.9% sodium chloride solution, 1.2-2.4 g 1 once a day and combined methods of endoscopic hemostasis) improving the quality of treatment and aimed at eliminating recurrence of bleeding.
Patients of the main group were performed along with endoscopic diathermocoagulation, infiltration of the bleeding site was performed by injection and irrigation with 96% alcohol. In the same group of patients, according to indications, other methods of injection hemostasis could be used. In this case, 96% ethyl alcohol is injected 1 mm directly from the source of bleeding at 4 points.
Conclusion. There were no deaths in the main group of patients. Conducting a combined method of hemostasis and correction of impaired liver functions in CDLD together with cytoprotective therapy, it is possible to reduce the number of recurrences of bleeding and avoid risky and pathogenetically unjustified surgical interventions. This tactic made it possible to reduce the number of operations in the main group in only 1 (0.7%) patients, against 6 (4.6%) in the control group .

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Published

2022-11-19

How to Cite

Urokov Sh. T, Khamroev B.S, & Hamroyev Kh.N. (2022). RESULTS OF TREATMENT OF PATIENTS WITH BLEEDING OF THE STOMACH AND 12 DUO FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS - INDUCED OENP. Journal of Pharmaceutical Negative Results, 1901–1910. https://doi.org/10.47750/pnr.2022.13.S09.228

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