Nano-progesterone: An improvised therapeutic approach

Authors

  • Afsana Sheikh
  • Gaurav K Jain
  • Jagriti Sharma
  • Nimesh Modi
  • Tejas Kothari
  • Nazeer Hasan
  • Nitin Sharma
  • Amirhossein Sahebkar
  • Prashant Kesharwani

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.157

Keywords:

oral bioavailability; nanonized progesterone; sustained release tablet; solubility; drug delivery.

Abstract

Progesterone (PG) is a natural steroid secreted during the luteal phase by the corpus luteum. It is highly required for the release of oocytes, embryo implantation and retaining and maintaining pregnancy. However, due to hydrophobic nature, its biological half-life is extremely less due to which oral delivery of PG is near to impossible. To improve its efficiency and overcome such pitfalls researchers are developing novel drug delivery system (NDDS) for sustained delivery of PG. This review highlights the major hurdles of PG administration via oral route and the application of NDDS for the delivery of progesterone.

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Published

2022-11-17 — Updated on 2022-11-28

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How to Cite

Afsana Sheikh, Gaurav K Jain, Jagriti Sharma, Nimesh Modi, Tejas Kothari, Nazeer Hasan, Nitin Sharma, Amirhossein Sahebkar, & Prashant Kesharwani. (2022). Nano-progesterone: An improvised therapeutic approach. Journal of Pharmaceutical Negative Results, 1315–1320. https://doi.org/10.47750/pnr.2022.13.S09.157 (Original work published November 17, 2022)

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