Nano-progesterone: An improvised therapeutic approach
Keywords:oral bioavailability; nanonized progesterone; sustained release tablet; solubility; drug delivery.
Progesterone (PG) is a natural steroid secreted during the luteal phase by the corpus luteum. It is highly required for the release of oocytes, embryo implantation and retaining and maintaining pregnancy. However, due to hydrophobic nature, its biological half-life is extremely less due to which oral delivery of PG is near to impossible. To improve its efficiency and overcome such pitfalls researchers are developing novel drug delivery system (NDDS) for sustained delivery of PG. This review highlights the major hurdles of PG administration via oral route and the application of NDDS for the delivery of progesterone.