Assessment Of Total Serum Creatine Phosphokinase And Serum Lactate Dehydrogenase Levels In Patients With Oral Cancer And Oral Leukoplakia

Authors

  • Dr. Pramod S Ingaleshwar , Dr. Syed AltafUddin Quadri , Dr. Uzma Talath , Dr. Sajid.T.Hussain , Dr. Sangavi R. , Dr. Sushanthi Suresh

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.153

Abstract

Background: Oral Squamous cell carcinoma (OSCC) is a multistage process, from normal to dysplastic cells (precancerous lesions) and ultimately to squamous cell carcinoma. The present study was conducted to assess total serum creatine phosphokinase and serum lactate dehydrogenase levels in patients with oral cancer and oral leukoplakia.

Materials & Methods: 50 patients of oral cancer and oral leukoplakia of both genders were included. Oral cancer patients were kept in group I (25) and oral leukoplakia in group II (25). 25 healthy controls were kept in group III. 5 mL of venous blood was collected and biochemical estimation of serum CK and LDH levels using Siemens autoanalyzer was done.

Results: Group I had 15 males and 10 females, group II had 16 males and 9 females and group III had12 males and 13 females. The mean LDH level in group I 314.5 IU/L, in group II was 289.4 IU/L and in group III was 140.7 IU/L. The difference was significant (P< 0.05). The mean CPK in group I was 70.4 IU/L, in group II was 76.8 IU/L and in group III was 104.5 IU/L. The difference was significant (P< 0.05).

Conclusion: Quantification of serum LDH and CK can be potentially used as a biochemical marker, as it is a simple, non-invasive procedure in patients with OSCC and Oral cancer.

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Published

2022-11-17 — Updated on 2022-11-17

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Dr. Pramod S Ingaleshwar , Dr. Syed AltafUddin Quadri , Dr. Uzma Talath , Dr. Sajid.T.Hussain , Dr. Sangavi R. , Dr. Sushanthi Suresh. (2022). Assessment Of Total Serum Creatine Phosphokinase And Serum Lactate Dehydrogenase Levels In Patients With Oral Cancer And Oral Leukoplakia. Journal of Pharmaceutical Negative Results, 1288–1292. https://doi.org/10.47750/pnr.2022.13.S09.153

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