Mechanisms Of L-Carnitine For Mitigating Activity Of Dimethoate Insecticide Induced - Male Reproductive Toxicity In Rats

Authors

  • Mostafa Abbas Shalaby , Rehab Ali. Ghandour and Shimaa Ramadan Emam

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.147

Abstract

Mechanisms of dimethoate (DIM) induced – male reproductive toxixity  in rats and ameliorating role of L-carnitine (LC) were studied. Five groups of male rats were used.  G1: given corn oil (vehicle); G2 and 3 were orally given 20 and 40 mg/kg of DIM, respectively and G4 and 5 were given 20 mg/kg DIM + 100 mg/kg LC and 40 mg/kg DIM + LC, respectively. Weights of sexual organs, semen picture, testosterone levels, acetylcholinesterase (AchE) activity, lipid profile, lipid peroxidation, antioxidant enzymes activity and testis histopathology were performed. DIM significantly decreased the testis weight, deteriorated semen picture, decreased serum testosterone levels and inhibited AchE activity. Total cholesterol, triglycerides and low density lipoprotein were significantly increased. DIM increased testicular malondialdehyde (MDA) and decreased reduced glutathione (GLH) levels and antioxidant enzymes activities. Histopathology showed mild to moderate testicular damage with edema and presence of either few sperms in seminifrous tubules or azoospermia. DIM induced testicular damage in rats by induction of oxidative stress and lipid peroxidation, inhibition of AchE activity, reduction of testosterone biosynthesis and abnormalities of lipid profile. LC mitigated the above mentioned parameters via activating antioxidant enzymes and increasing testosterone secretion, activating AchE and preventing lipid peroxidation, denoting  ameliorating effect of LC.

Downloads

Published

2022-11-16 — Updated on 2022-11-16

Versions

How to Cite

Mostafa Abbas Shalaby , Rehab Ali. Ghandour and Shimaa Ramadan Emam. (2022). Mechanisms Of L-Carnitine For Mitigating Activity Of Dimethoate Insecticide Induced - Male Reproductive Toxicity In Rats. Journal of Pharmaceutical Negative Results, 1244–1256. https://doi.org/10.47750/pnr.2022.13.S09.147

Issue

Section

Articles