Gingival Crevicular Fluid-An Eos of Biomarkers
Keywords:GCF, PGE2, AST, NE, ALT, PMN.
GCF is a serum transudate or inflammatory exudate that is derived from the periodontal tissues and can be collected at the orifice or from within the
gingival crevice.(1) The potential diagnostic importance of gingival fluid was recognized more than 60 years ago and serious investigation of the dynamics
of GCF production did not begin until the late 1950s with the reports of Brill and co-workers.(2,3) The fluid component of GCF derives primarily from
microvascular leakage. Additions to the fluid volume are made from the intercellular fluid and cellular cytoplasm. The gingival tissue is constantly
subjected to mechanical and bacterial aggregation.Resistance to these actions is provided by saliva, sulcular fluid, epithelial surface keratinisation and
initial stages of inflammation.(4) The origin,composition and clinical significance of gingival crevicular fluid have significantly helped us in
understanding the pathogenesis of periodontal disease.
The need to find a non-invasive test method in periodontitis drew attention to the sulcus fluid that is produced in small quantities even in a completely
healthy periodontium, and its composition is near similar to that of blood plasma.