Study Of (NF-Κb) Gene Expression As A Biomarker For Development Of Cardiovascular Disease In Type 2 Diabetes

Authors

  • Mervat Kamil kadhim and Alaa Mohammad Hasson Al-Husseini

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.66

Abstract

The purpose of this research is to see if there is a link between diabetes type 2 complications and the level of nuclear factor kappa B (NF-κB) overexpression.

Ninety blood samples were collected from individuals and divided into three groups, each group involved thirty samples: the first group representing individuals with (hypertensive type 2 diabetes ) ,the second group representing (hypertensive type 2 diabeteswith cardiovascular diseases), and the last group was represented by a control group.

mRNA was extracted from blood samples then converted to cDNA by using the (qPCR) technique.  The outcomes revealed a significant increase (p<0.05) in expression of  mRNANF-κB in both groups compared to the control group and this over- expression in hypertensive type 2 diabetes with cardiovascular diseases more than hypertensive type 2 diabetes. The NF-κB gene was studied in type 2 diabetes and cardiovascular disease in the current study, and it could be a novel target for early CVD therapy in the future.

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Published

2022-11-11 — Updated on 2022-11-11

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How to Cite

Mervat Kamil kadhim and Alaa Mohammad Hasson Al-Husseini. (2022). Study Of (NF-Κb) Gene Expression As A Biomarker For Development Of Cardiovascular Disease In Type 2 Diabetes. Journal of Pharmaceutical Negative Results, 599–604. https://doi.org/10.47750/pnr.2022.13.S09.66

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