The Biochemical Assessments of Cellular Oxidant - Antioxidant Status and Lipid Profile for Some of COVID-19 Vaccines (Pfizer, AstraZeneca and Sinopharm) in Vaccinated People of Wasit Province in Iraq

Authors

  • Tahrir Ghali Resan Al-Salmi
  • Jafar Abass Issa Al-Maamori

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.007

Keywords:

COVID-19 vaccine, vaccine efficiency, biochemical assessment after COVID-19 vaccination, Oxidation balance after COVID-19 vaccine.

Abstract

Background: Coronaviruses (SARS-CoV-2) cause COVID-19 pandemic in March, 2020, after Chinese scientists published the genome of the virus vaccine manufacturer produced several COVID-19 vaccines that aimed to induce a humoral and cellular immune response to prevent the fatality and harm caused by COVID-19. Existing study aimed to evaluate the biochemical efficiency of some of COVID-19 vaccines (Pfizer, AstraZeneca and Sinopharm) in vaccinated people of Wasit Province in Iraq by lipid profile estimation, Human SOD1 (Superoxide Dismutase 1, Soluble) and Human Malondialdehyde (MDA).
Methods: The current study sample included (55) individuals whom vaccinated with two shots of one of the three vaccines (Pfizer, AstraZeneca and Sinopharm) whom did not suffer from chronic health problems, and a control group of (35) unvaccinated individuals of both genders. Their age ranges from 18-45 years, they were divided into two age ranges (18-31 and 32-45 years) and their vaccination history was confirmed according to a special form. The blood samples were collected from fasting vaccinated individuals 2-4 weeks post the second dose of COVID-19 vaccine for the purpose of conducting lipid profile, SOD and MDA.
RESULTS: The data of serous endogenous oxidative–antioxidants balance showed a variation in the concentrations of malondialdehyde (MDA), its significant increase (P≤0.05) was observed in those vaccinated with the Pfizer vaccine for the first age range (31-18 years) and its insignificant decrease (P> 0.05) in the two Sinopharm and AstraZeneca vaccines in both age ranges and both genders comparing to the control group. Besides, the findings of estimating the serum level of enzyme Superoxide dismutase (SOD) was not significantly different (P> 0.05) between the vaccinated people of this study for all three vaccines and the control group for both age ranges and both genders. Additionally, the serum lipid profile levels (TG, LDL, HDL and VLDL) of the vaccinated individuals were not significantly changed (P>0.05) compared to the control group (unvaccinated individuals) except for the cleared variation in cholesterol level among the first age range for both genders compared to the control group.
Conclusion: the findings of the present study showed that all the three targeted vaccines in the study (Pfizer, AstraZeneca and Sinopharm) have shown a high efficacy and safely on body oxidation balance and heart in terms of the biochemical assessment (MDA, SOD and lipid profile) of the healthy vaccinated participants.

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Published

2022-11-07

How to Cite

Tahrir Ghali Resan Al-Salmi, & Jafar Abass Issa Al-Maamori. (2022). The Biochemical Assessments of Cellular Oxidant - Antioxidant Status and Lipid Profile for Some of COVID-19 Vaccines (Pfizer, AstraZeneca and Sinopharm) in Vaccinated People of Wasit Province in Iraq. Journal of Pharmaceutical Negative Results, 70–78. https://doi.org/10.47750/pnr.2022.13.S09.007

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Articles