Adult Patients With Liver Cirrhosis And Portal Vein Thrombosis: An Experience At A Tertiary Care Hospital
BACKGROUND: Portal vein thrombosis (PVT) is more common in patients with liver cirrhosis, and its prevalence increases with the severity of liver disease. PVT can lead to various complications like variceal bleeding and mesenteric ischemia. The study's main aim was to determine the prevalence of PVT in liver cirrhosis patients and ascertain its relationship with the severity of liver disease.
METHODS: After approval from the hospital's ethical committee, the study was carried out at the Department of Gastroenterology at Hayatabad Medical Complex Peshawar. One hundred and ninety-three patients with cirrhosis who met the criteria were included. All participants provided their informed consent. Patients were classified into three groups based on their Child-Pugh score. Ultrasound abdomen and Doppler ultrasound of the portal vein were done in all patients to diagnose PVT. SPSS version 25 was used for the analysis of the data.
RESULTS: A total of 193 patients were assessed. The mean age was 50.25 ± 8.56. The ratio of male to female was 2.8:1. Hepatitis C (78.2%) was the predominant etiology of cirrhosis. Most of the patients in this study had Child-Pugh Class C (43%), followed by Child-Pugh Class B (34.7%) and Child-Pugh Class A (22.3%). PVT was present overall in 13.47% of patients. The PVT frequency was higher in Child-Pugh Class C patients than Child-Pugh Class B and A patients. However, the difference in the frequency of PVT among different Child Pugh Classes was not statistically significant (p=0.202).In the same way, PVT was more prevalent in patients with cirrhosis due to underlying hepatitis C; however, the difference was not statistically significant (p=0.718).
CONCLUSION: In patients with cirrhosis, portal vein thrombosis is a common finding. Overall, 13.47% of patients in this study had PVT. PVT was observed more frequently in patients with advanced cirrhosis (Child-Pugh Class C) and those with cirrhosis due to hepatitis C. However, in our study, PVT did not have a significant association with the Child-Pugh Class, gender, or the etiology of cirrhosis.