Synthesis, Characterization And Antimicrobial Screening Of Sulfadiazine-2-Azetidinone-1,2,4-Triazole Clubbed Derivatives

Abstract

Sulfadiazine, IUPAC namely 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) was condensed with aromatic aldehydes to get Schiff’s bases, 4-(arylidene amino)-N-(pyrimidin-2-yl) benzene sulfonamide (3a-g). These were on cyclo condensation with chloro acetyl chloride afford 2-Azetidinone derivatives, 4-(3-chloro -2-oxo-4-arylazetidin-1-yl)-N-(pyrimidin-2-yl)benzene sulfonamide(4a-g). So called azetidinone derivatives were then on nucleophilic substituted reaction with 3,5-dibromo-1H-1,2,4-triazole and obtained the derivatives 4-(3-(3,5-dibromo-1H-1,2,4-triazol-1-yl)-2-oxo-4-arylazetidin-1-yl)-N-(pyrimidin-2-yl)benzene sulfonamide (5a-g). All the three series of compounds 3a-g, 4a-g and 5a-g were characterized by elemental content and spectral features. The antimicrobial activities of all the compounds also were monitored against common pathogens.