Synthesis, Characterization And Antimicrobial Activity Of Azetidinone Derivatives Based On 4-Amino-N-(4h-1,2,4-Triazol-4-Yl)Benzenesulfonamide

Abstract

The 4H-1,2,4-triazol-4-amine (1)  reacted with 4-acetamidobenzene-1-sulfonyl chloride (2) followed by hydrolyzed to yield 4-amino-N-(4H-1,2,4-triazol-4-yl)benzene sulfonamide (3). The compound (3) was then condensed with various aromatic aldehydes (4a-g) afforded Schiff bases, 4-(arylideneamino)-N-(4H-1,2,4-triazol-4-yl) benzene sulfonamide (5a-g). These (5a-g) further condensed with chloro acetyl chloride to novel azitidinone derivatives namely,4-(3-chloro-2-oxo -4-arylazetidin-1-yl)-N-(4H -1,2,4-triazol-4-yl) benzene sulfonamide (6a-g). On reaction of (6a-g) with 3,5-dichloro-1H-1,2,4-triazole yielded 4-(3(3,5-di chloro-1H-1,2,4-triazol-1-yl)-2-oxo-4-arylazetidin-1-yl)-N-(4H-1,2,4-triazol-4-yl) benzene sulfonamide (7a-g). The elemental analysis and Spectroscopy techniques were used to determined the structure of all the novel synthesised compounds. The antibacterial and antifungal activities of novel synthesized compounds were tested.