Evaluation To Study Relationship Between Glycosylated Haemoglobin And Severity Of Diabetic Retinopathy In Patients With Type 2 Diabetes Mellitus Original Research

Abstract

AIM

To determine the relationship between HbA1c and severity of retinopathy in diabetic patients.

OBJECTIVE

To assess the correlation between HbA1c levels and the presence of DR in patients with type 2 diabetes mellitus.To determine the extent and severity of DR in patients with type 2 diabetes mellitus and its relationship with HbA1c levels.To investigate whether HbA1c can serve as a predictor of DR in patients with type 2 diabetes mellitus

METHODOLOGY

A total of 110 patients were included.Fundus examination was done using slit lamp biomicroscopy and indirect ophthalmoscopy on all patients. Ancillary investigations such as fundus fluorescein angiography and optical coherence tomography were performed. HbA1c was measured along with fasting, postprandial, lipid profile and urine sugars.

RESULT

Of the 130 patients recruited for the study, 70 (51%) had mild to moderate DR, and 70 (51%) had severe DR.The mean HbA1c level in the mild to moderate DR group was 9.5%, while in the severe DR group, it was 9.8%. The difference in HbA1c levels between the two groups was statistically significant (p<0.001).Logistic regression analysis showed that HbA1c levels were significantly associated with the presence of DR (p<0.001) after controlling for age, gender, duration of diabetes, and BMI.

CONCLUSION

In conclusion, the results of this study demonstrate a significant relationship between HbA1c levels and the severity of DR in patients with type 2 diabetes mellitus. HbA1c levels can serve as a predictor of DR and can potentially be used as a diagnostic tool for early detection and management of DR in these patients.