Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm

Viktor N. Tsarev| Rafael V. Ushakov| Evgenii V. Ippolitov| Martiros S. Sarkisyan| Tatyana V. Tsareva| Tatyana P. Gerasimova| Alexey R. Ushakov| Elena N. Nikolaeva*

2021, Vol: 12, Issue: 1

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Original Article

PNR. 2021; 12(1): 33-37

doi: 10.47750/pnr.2021.12.01.006

Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm

Viktor N. Tsarev, Rafael V. Ushakov, Evgenii V. Ippolitov, Martiros S. Sarkisyan, Tatyana V. Tsareva, Tatyana P. Gerasimova, Alexey R. Ushakov, Elena N. Nikolaeva*.

Abstract
Objective: The study of subgingival biofilm composition in patients with ischemic heart disease and concomitant periodontitis.
Study design: For the study, 45 patients with moderate chronic periodontitis were examined. They were divided into three groups. Group 1 included 15 patients with acute myocardial infarction, Group 2–15 included patients with exertional angina (pectoris) and Group 3–15 included patients without cardiovascular diseases. Dental and cardiological health condition was determined, a biochemical blood test was conducted, brachial artery endothelium-dependent vasodilation was measured, and periodontopathogenic bacteria DNA in subgingival biofilm was detected.
Results: Frequency of P. gingivalis, T. forsythia, and A. actinomycetemcomitans detection in Group 1 was significantly higher than in Group 3. In patients of Group 1 and Group 2 subgingival biofilm contained P. gingivalis two times more often (p = 0.027), while P. intermedia – four times less often (p = 0.006) than in Group 3. Presence of P. gingivalis and A. actinomycetemcomitans was related to periodontal destruction level. Brachial artery endothelium-dependent vasodilation moderately correlated with patient’s cardiological condition (r = 0.3284), biochemical markers of atherosclerosis (r = 0.6465), and frequency of P. intermedia detection in periodontal pockets (r = 0.3828). Values of brachial artery endothelium-dependent vasodilation in Group 1 and Group 2 were statistically significantly lower than in Group 3 (p < 0.05).
Conclusions: A reliable relationship between parodontopathogenic bacteria colonization and development of acute myocardial infarction was established. In all patients with chronic periodontitis, endothelial dysfunction was observed, but brachial artery endothelium-dependent vasodilation was significantly lower in patients with concomitant cardiovascular diseases, which could be used for pathology prognosis

Key words: acute myocardial infarction, DNA, endothelium-dependent vasodilation, periodontitis, periodontopathogenic bacteria, subgingival biofilm.

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How to Cite this Article

Pubmed Style

Tsarev VN, Ushakov RV, Ippolitov EV, Sarkisyan MS, Tsareva TV, Gerasimova TP, Ushakov AR, Nikolaeva EN. Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. PNR. 2021; 12(1): 33-37. doi:10.47750/pnr.2021.12.01.006

Web Style

Tsarev VN, Ushakov RV, Ippolitov EV, Sarkisyan MS, Tsareva TV, Gerasimova TP, Ushakov AR, Nikolaeva EN. Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. http://www.pnrjournal.com/?mno=91594 [Access: November 10, 2021]. doi:10.47750/pnr.2021.12.01.006

AMA (American Medical Association) Style

Tsarev VN, Ushakov RV, Ippolitov EV, Sarkisyan MS, Tsareva TV, Gerasimova TP, Ushakov AR, Nikolaeva EN. Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. PNR. 2021; 12(1): 33-37. doi:10.47750/pnr.2021.12.01.006

Vancouver/ICMJE Style

Tsarev VN, Ushakov RV, Ippolitov EV, Sarkisyan MS, Tsareva TV, Gerasimova TP, Ushakov AR, Nikolaeva EN. Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. PNR. (2021), [cited November 10, 2021]; 12(1): 33-37. doi:10.47750/pnr.2021.12.01.006

Harvard Style

Tsarev, V. N., Ushakov, . R. V., Ippolitov, . E. V., Sarkisyan, . M. S., Tsareva, . T. V., Gerasimova, . T. P., Ushakov, . A. R. & Nikolaeva, . E. N. (2021) Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. PNR, 12 (1), 33-37. doi:10.47750/pnr.2021.12.01.006

Turabian Style

Tsarev, Viktor N., Rafael V. Ushakov, Evgenii V. Ippolitov, Martiros S. Sarkisyan, Tatyana V. Tsareva, Tatyana P. Gerasimova, Alexey R. Ushakov, and Elena N. Nikolaeva. 2021. Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. Journal of Pharmaceutical Negative Results, 12 (1), 33-37. doi:10.47750/pnr.2021.12.01.006

Chicago Style

Tsarev, Viktor N., Rafael V. Ushakov, Evgenii V. Ippolitov, Martiros S. Sarkisyan, Tatyana V. Tsareva, Tatyana P. Gerasimova, Alexey R. Ushakov, and Elena N. Nikolaeva. "Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm." Journal of Pharmaceutical Negative Results 12 (2021), 33-37. doi:10.47750/pnr.2021.12.01.006

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Tsarev, V. N., Ushakov, . R. V., Ippolitov, . E. V., Sarkisyan, . M. S., Tsareva, . T. V., Gerasimova, . T. P., Ushakov, . A. R. & Nikolaeva, . E. N. (2021) Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. Journal of Pharmaceutical Negative Results, 12 (1), 33-37. doi:10.47750/pnr.2021.12.01.006

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