E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats

Aseel J Ali, Huda G Hameed, Ihab A Ahmad, Marwan S Al-Nimer.

Abstract
Topical application of dimethybenz[a]anthracene (DMBA) on the oral mucosa is an experimental ‎model of tumorigenesis that widely used for assessing of chemopreventive substances. Camellia ‎sinensis contains polyphenols and flavonoids that act as antioxidants and anticancer. White tea ‎infusion contains a lower concentration of polyphenols compared with green or red tea. This ‎study aimed to investigate the effect of using white tea infusion on the DMBA-induced oral ‎tumor by assessing biomarkers related to the development of oral tumor. DMBA (0.5% w/v ‎dissolved in acetone) was applied topically to the oral mucosa, five times weekly for twelve ‎weeks followed by tape water infusion or white tea infusion (10% w/v) for another eight weeks. ‎Serum biomarkers related to the tumorigenesis including, C-reactive protein (CRP), tumor ‎necrosis factor (TNF-α), epidermal growth factor receptor (EGFR), and carcinoembryonic ‎antigen (CEA) were determined. Serum level of CEA and the ratio of EGFR-to TNF-α were ‎significantly increased in rats treated with white tea infusion compared with rats treated with ‎tape water. Thus, white tea infusion at 10%w/v for 8 weeks provokes oral tumor induced by a ‎topical application of DMBA by the evidence of a significantly increased the values of ‎biomarkers related to tumorigenesis.‎

Key words: dimethybenz[a]anthracene, white tea, oral mucosa, tumorigenesis biomarkers


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Aseel J Ali
Articles by Huda G Hameed
Articles by Ihab A Ahmad
Articles by Marwan S Al-Nimer
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. 2021; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001


Web Style

AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. http://www.pnrjournal.com/?mno=83559 [Access: January 12, 2022]. doi:10.47750/pnr.2021.12.02.001


AMA (American Medical Association) Style

AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. 2021; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001



Vancouver/ICMJE Style

AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. (2021), [cited January 12, 2022]; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001



Harvard Style

, A. J. A., , . H. G. H., , . I. A. A. & Al-Nimer, . M. S. (2021) White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001



Turabian Style

, Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. 2021. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. Journal of Pharmaceutical Negative Results, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001



Chicago Style

, Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. "White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats." Journal of Pharmaceutical Negative Results 12 (2021), 1-5. doi:10.47750/pnr.2021.12.02.001



MLA (The Modern Language Association) Style

, Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. "White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats." Journal of Pharmaceutical Negative Results 12.2 (2021), 1-5. Print. doi:10.47750/pnr.2021.12.02.001



APA (American Psychological Association) Style

, A. J. A., , . H. G. H., , . I. A. A. & Al-Nimer, . M. S. (2021) White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. Journal of Pharmaceutical Negative Results, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001





Most Viewed Articles
  • Pharmacoepidemiology of Antiepileptic Drugs in Children
    Darya Knyazeva, Yulia Gushchina, Oksana Zakharova
    PNR. 2021; 12(1): 1-6
    » Abstract » doi: 10.47750/pnr.2021.12.01.001

  • Comparative Benefits of Statins in Coronary Heart Disease
    Viktoriya Ermakova, Hizir Bataev, Natalya Semenenko
    PNR. 2021; 12(1): 7-13
    » Abstract » doi: 10.47750/pnr.2021.12.01.002

  • Influence of polylactic acid and polycaprolactone on dissolution characteristics of ansamycin-loaded polymeric nanoparticles: An unsatisfied attempt for drug release profile
    Keerthi GS Nair, Ramaiyan Velmurugan, Sathesh Kumar Sukumaran
    PNR. 2020; 11(1): 23-29
    » Abstract » doi: 10.4103/jpnr.JPNR_26_19

  • Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review
    Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan
    PNR. 2019; 10(1): 6-15
    » Abstract » doi: 10.4103/jpnr.JPNR_3_19

  • Ethical Issues of Decision Making and Communication in Health Care: An Intercultural and Interfaith Perspective
    Elena Grunt, Alexander Ivanov, Elena Zubko, Vladimir Starostin
    PNR. 2021; 12(1): 27-32
    » Abstract » doi: 10.47750/pnr.2021.12.01.005

  • Most Downloaded
  • Lack of activity of rutin isolated from Tontelea micrantha leaves against Vero and BHK, fungi, bacteria and Mayaro virus and its in silico activity
    Waleska Stephanie Da Cruz Nizer, Ariane Coelho Ferraz, Thais De Fatima Silva Moraes, Fernanda Lopes Ferreira, Cintia Lopes De Brito Magalhes, Sidney Augusto Vieira-Filho, Lucenir Pains Duarte, Jos Carlos De Magalhes
    PNR. 2020; 11(1): 9-14
    » Abstract » doi: 10.4103/jpnr.JPNR_12_19

  • No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis
    Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda
    PNR. 2020; 11(1): 1-8
    » Abstract » doi: 10.4103/jpnr.JPNR_22_19

  • Neurobehavioral activity study of methanolic whole plants extract of Cyperus rotundus Linn.
    Imonul Kabir, Subir Biswas, Md Asaduzzaman, Md Islam Molla, Md Rajdoula Rafe
    PNR. 2019; 10(1): 36-40
    » Abstract » doi: 10.4103/jpnr.JPNR_11_19

  • Antimicrobial effect of chloroform Hibiscus sabdariffa extract on pathogenic bacteria
    Elaheh Aleebrahim-Dehkordy, Mahmoud Rafieian-Kopaei, Behnam Zamanzad, Fatemeh Deris, Abolghasem Sharifih, Ali Reyhanian
    PNR. 2020; 11(1): 15-18
    » Abstract » doi: 10.4103/jpnr.JPNR_19_18

  • Antimicrobial resistance and presence of Class 1 integrons in Pseudomonas aeruginosa isolates from burn and wound infections
    Ali Hassoun Hammadi, Qutaiba Ahmed Al Khames Aga, Nabil Awni Nimer, Pottathil Shinu, Anroop B Nair
    PNR. 2020; 11(1): 19-22
    » Abstract » doi: 10.4103/jpnr.JPNR_9_20

  • Most Cited Articles