E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats

Aseel J Ali, Huda G Hameed, Ihab A Ahmad, Marwan S Al-Nimer.

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  • Abstract
    Topical application of dimethybenz[a]anthracene (DMBA) on the oral mucosa is an experimental ‎model of tumorigenesis that widely used for assessing of chemopreventive substances. Camellia ‎sinensis contains polyphenols and flavonoids that act as antioxidants and anticancer. White tea ‎infusion contains a lower concentration of polyphenols compared with green or red tea. This ‎study aimed to investigate the effect of using white tea infusion on the DMBA-induced oral ‎tumor by assessing biomarkers related to the development of oral tumor. DMBA (0.5% w/v ‎dissolved in acetone) was applied topically to the oral mucosa, five times weekly for twelve ‎weeks followed by tape water infusion or white tea infusion (10% w/v) for another eight weeks. ‎Serum biomarkers related to the tumorigenesis including, C-reactive protein (CRP), tumor ‎necrosis factor (TNF-α), epidermal growth factor receptor (EGFR), and carcinoembryonic ‎antigen (CEA) were determined. Serum level of CEA and the ratio of EGFR-to TNF-α were ‎significantly increased in rats treated with white tea infusion compared with rats treated with ‎tape water. Thus, white tea infusion at 10%w/v for 8 weeks provokes oral tumor induced by a ‎topical application of DMBA by the evidence of a significantly increased the values of ‎biomarkers related to tumorigenesis.‎

    Key words: dimethybenz[a]anthracene, white tea, oral mucosa, tumorigenesis biomarkers


     
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    How to Cite this Article
    Pubmed Style

    AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. 2021; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001


    Web Style

    AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. https://www.pnrjournal.com/?mno=83559 [Access: August 11, 2022]. doi:10.47750/pnr.2021.12.02.001


    AMA (American Medical Association) Style

    AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. 2021; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001



    Vancouver/ICMJE Style

    AJA, HGH, IAA, Al-Nimer MS. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR. (2021), [cited August 11, 2022]; 12(2): 1-5. doi:10.47750/pnr.2021.12.02.001



    Harvard Style

    , A. J. A., , . H. G. H., , . I. A. A. & Al-Nimer, . M. S. (2021) White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. PNR, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001



    Turabian Style

    , Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. 2021. White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. Journal of Pharmaceutical Negative Results, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001



    Chicago Style

    , Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. "White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats." Journal of Pharmaceutical Negative Results 12 (2021), 1-5. doi:10.47750/pnr.2021.12.02.001



    MLA (The Modern Language Association) Style

    , Aseel J Ali, Huda G Hameed, Ihab A Ahmad, and Marwan S Al-Nimer. "White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats." Journal of Pharmaceutical Negative Results 12.2 (2021), 1-5. Print. doi:10.47750/pnr.2021.12.02.001



    APA (American Psychological Association) Style

    , A. J. A., , . H. G. H., , . I. A. A. & Al-Nimer, . M. S. (2021) White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. Journal of Pharmaceutical Negative Results, 12 (2), 1-5. doi:10.47750/pnr.2021.12.02.001