E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Pharmacoepidemiology of Antiepileptic Drugs in Children

Darya Knyazeva, Yulia Gushchina, Oksana Zakharova.

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  • Abstract
    With the pharmacotherapy of epilepsy, there is a decrease in the number of seizures or their complete cessation. The aim of the study was to conduct a comparative analysis of the efficacy and safety of antiepileptics traditionally used in medicine (valproate, carbamazepine) and new-generation analogs (topiramate) in the treatment of epilepsy in children and adolescents. The study was conducted in 2014 and 2018, at the Center for Epileptology and Neurology, Moscow (Russian Federation). In 2014, 777 medical records of children registered with epilep¬tologists were studied, in 2018 - 840 medical records of children. The age interval of 3 months is 18 years. Favorable outcomes of epilepsy therapy with different drugs were calculated, with different approaches monotherapy and polytherapy. A favorable outcome meant remis¬sion, which lasted more than 1 year and more than 3 years. In 2014 and 2018, monotherapy prevailed among the treatment methods. With monotherapy, valproates are used more often (up to 70%), carbamazepine is used 3.0 times less often (p ≤ 0.01 relative to valproates). The use of topiramate is 10 times less than the number of valproate therapy (p ≤ 0.0001), and barbiturates - 15 times (p ≤ 0.0001). Among the new gen¬eration drugs, topiramate was often used, with monotherapy, with symptomatic forms of epilepsy (10.4% in 2014 and 7.9% in 2018, p ≤ 0.05), as well as with a cryptogenic form (9.6% and 4.4%, respectively, p ≤ 0.05). The chosen type of therapy can significantly affect the number of side effects. With polytherapy, in 2014, side effects were observed
    in 44.1% compared with monotherapy (18.1%, at p ≤ 0.01), in 2018 - 45.1% against 20.9% (at p ≤ 0.01). Topiramate showed lower efficacy compared with carbamazepine in all years of the study with monother¬apy (0.65, at p ≤ 0.04). The results did not confirm the effectiveness of the new drugs. There was no difference in efficacy and safety between traditional drugs (valproate, carbamazepine) and new generation drugs (topiramate and others). In 2014 and 2018, monotherapy (72.8%) over polytherapy (27.2%) prevailed among the treatment methods for epilepsy. Among the drugs, valproate was predominant (65.8%), and in all identified forms of epilepsy. The new generation of drugs did not show statistically significant advantages compared to traditionally used ones. The method of polytherapy of epilepsy in children gives a twofold increase in the likelihood of side effects (p ≤ 0.01).

    Key words: epilepsy, pharmacotherapy, monotherapy, polytherapy, children, valproate, carbamazepine, topiramate.


     
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    How to Cite this Article
    Pubmed Style

    Knyazeva D, Gushchina Y, Zakharova O. Pharmacoepidemiology of Antiepileptic Drugs in Children. PNR. 2021; 12(1): 1-6. doi:10.47750/pnr.2021.12.01.001


    Web Style

    Knyazeva D, Gushchina Y, Zakharova O. Pharmacoepidemiology of Antiepileptic Drugs in Children. https://www.pnrjournal.com/?mno=68469 [Access: May 21, 2022]. doi:10.47750/pnr.2021.12.01.001


    AMA (American Medical Association) Style

    Knyazeva D, Gushchina Y, Zakharova O. Pharmacoepidemiology of Antiepileptic Drugs in Children. PNR. 2021; 12(1): 1-6. doi:10.47750/pnr.2021.12.01.001



    Vancouver/ICMJE Style

    Knyazeva D, Gushchina Y, Zakharova O. Pharmacoepidemiology of Antiepileptic Drugs in Children. PNR. (2021), [cited May 21, 2022]; 12(1): 1-6. doi:10.47750/pnr.2021.12.01.001



    Harvard Style

    Knyazeva, D., Gushchina, . Y. & Zakharova, . O. (2021) Pharmacoepidemiology of Antiepileptic Drugs in Children. PNR, 12 (1), 1-6. doi:10.47750/pnr.2021.12.01.001



    Turabian Style

    Knyazeva, Darya, Yulia Gushchina, and Oksana Zakharova. 2021. Pharmacoepidemiology of Antiepileptic Drugs in Children. Journal of Pharmaceutical Negative Results, 12 (1), 1-6. doi:10.47750/pnr.2021.12.01.001



    Chicago Style

    Knyazeva, Darya, Yulia Gushchina, and Oksana Zakharova. "Pharmacoepidemiology of Antiepileptic Drugs in Children." Journal of Pharmaceutical Negative Results 12 (2021), 1-6. doi:10.47750/pnr.2021.12.01.001



    MLA (The Modern Language Association) Style

    Knyazeva, Darya, Yulia Gushchina, and Oksana Zakharova. "Pharmacoepidemiology of Antiepileptic Drugs in Children." Journal of Pharmaceutical Negative Results 12.1 (2021), 1-6. Print. doi:10.47750/pnr.2021.12.01.001



    APA (American Psychological Association) Style

    Knyazeva, D., Gushchina, . Y. & Zakharova, . O. (2021) Pharmacoepidemiology of Antiepileptic Drugs in Children. Journal of Pharmaceutical Negative Results, 12 (1), 1-6. doi:10.47750/pnr.2021.12.01.001