E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients

Shaimaa A. Al-Oubaidy, Sura A. Awadh.

Abstract
Background: The metabolic syndrome (MS) is a group of clinical disorders that includes central and abdominal obesity, systemic hypertension, insulin resistance (T2DM), and atherogenic dyslipidemia. It is also known as syndrome X, insulin resistance syndrome, and Reaven syndrome. The current study was carried out to assess the effects of MnSOD A16V genetic polymorphism on MS incidence in the Iraqi population. Methods: This study included 50 patients with MS (27 male and 23 female) at range of age (22-59 Y) and 50 subjects as control group with matching in age and genders. Insulin levels INS (µU/ml) were estimated by use of ELISA technique and insulin resistant index (IRI) was estimated by specific formula while FBG, TC, TG, LDL-C, and HDL-C (mg/dl) were performed by use spectrophotometric method. PCR-RFLP was done to investigation of the A16V MnSOD SNP. Results: The results show that the MS and CONT groups had significantly significant differences in INS (U/ml) and IRI (p-value 0.05). The results reveal statistical differences between MS and CONT genotypes AA and VV compared to AV genotypes. Conclusion: In the Iraqi population, the A16V MnSOD SNP plays a crucial role in the occurrence and progression of MS.

Key words: Metabolic syndrome, A16V SNP, MnSOD, Insulin, FBG


 
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How to Cite this Article
Pubmed Style

Al-Oubaidy SA, Awadh SA. Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. PNR. 2022; 13(1): 95-99. doi:10.47750/pnr.2022.13.01.017


Web Style

Al-Oubaidy SA, Awadh SA. Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. https://www.pnrjournal.com/?mno=4014 [Access: June 25, 2022]. doi:10.47750/pnr.2022.13.01.017


AMA (American Medical Association) Style

Al-Oubaidy SA, Awadh SA. Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. PNR. 2022; 13(1): 95-99. doi:10.47750/pnr.2022.13.01.017



Vancouver/ICMJE Style

Al-Oubaidy SA, Awadh SA. Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. PNR. (2022), [cited June 25, 2022]; 13(1): 95-99. doi:10.47750/pnr.2022.13.01.017



Harvard Style

Al-Oubaidy, S. A. & Awadh, . S. A. (2022) Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. PNR, 13 (1), 95-99. doi:10.47750/pnr.2022.13.01.017



Turabian Style

Al-Oubaidy, Shaimaa A., and Sura A. Awadh. 2022. Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. Journal of Pharmaceutical Negative Results, 13 (1), 95-99. doi:10.47750/pnr.2022.13.01.017



Chicago Style

Al-Oubaidy, Shaimaa A., and Sura A. Awadh. "Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients." Journal of Pharmaceutical Negative Results 13 (2022), 95-99. doi:10.47750/pnr.2022.13.01.017



MLA (The Modern Language Association) Style

Al-Oubaidy, Shaimaa A., and Sura A. Awadh. "Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients." Journal of Pharmaceutical Negative Results 13.1 (2022), 95-99. Print. doi:10.47750/pnr.2022.13.01.017



APA (American Psychological Association) Style

Al-Oubaidy, S. A. & Awadh, . S. A. (2022) Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. Journal of Pharmaceutical Negative Results, 13 (1), 95-99. doi:10.47750/pnr.2022.13.01.017