E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study

Sedighe J. Gandomani, Dhiya Altememy, Akram Alizadeh, Zeinab Tavakol, Pegah Khosravian.

Abstract
Introduction
Iranian traditional medicine has recommended the use of smoke from complete burning of jennet feces as a strong anti-inflammatory and wound healing component. Therefore, the present study was done to set up an animal model of cervicitis and production of vaginal cream of this smoke to evaluate anti-inflammatory effects of that in cervicitis.
Materials and Methods
We used 20 female vistar rats weighting 200-250 gr in 4 groups for animal model set up using different dosage of phenol and CMC for the first time. The vaginal cream was containing 5% jennet faces smoke. Groups were divided in to health, cervicitis model, control (receive base cream) and treatment (receive smoke cream). After induction of cervicitis, control and treatment groups were received base cream and 5% vaginal smoke cream respectively for five days. Vaginal pH was measured during of study. After 5 days, the cervix organs were examined by histopathological assay.
Result
No significant difference in vaginal pH in all of 4 groups of the intervention. In the model and control groups, we observed inflammatory cell infiltration and some visible epithelial erosion. After treatment with 5% vaginal smoke cream, the pathological features of cervicitis decreased significantly; inflammation (p = 0.011), vascular congestion (p = 0.001) and erosion scores (p> 0.005).
Conclusion
The smoke of jennet feces has anti-inflammatory effects on phenol-CMC induced cervicitis in rat model.

Key words: vaginal cream, smoke, feces, cervicitis, rat model


 
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How to Cite this Article
Pubmed Style

SJG, DA, AA, Tavakol Z, Khosravian P. Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. PNR. 2022; 13(2): 38-43. doi:10.47750/pnr.2022.13.02.006


Web Style

SJG, DA, AA, Tavakol Z, Khosravian P. Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. https://www.pnrjournal.com/?mno=31332 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.006


AMA (American Medical Association) Style

SJG, DA, AA, Tavakol Z, Khosravian P. Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. PNR. 2022; 13(2): 38-43. doi:10.47750/pnr.2022.13.02.006



Vancouver/ICMJE Style

SJG, DA, AA, Tavakol Z, Khosravian P. Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. PNR. (2022), [cited August 11, 2022]; 13(2): 38-43. doi:10.47750/pnr.2022.13.02.006



Harvard Style

, S. J. G., , . D. A., , . A. A., Tavakol, . Z. & Khosravian, . P. (2022) Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. PNR, 13 (2), 38-43. doi:10.47750/pnr.2022.13.02.006



Turabian Style

, Sedighe J. Gandomani, Dhiya Altememy, Akram Alizadeh, Zeinab Tavakol, and Pegah Khosravian. 2022. Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. Journal of Pharmaceutical Negative Results, 13 (2), 38-43. doi:10.47750/pnr.2022.13.02.006



Chicago Style

, Sedighe J. Gandomani, Dhiya Altememy, Akram Alizadeh, Zeinab Tavakol, and Pegah Khosravian. "Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study." Journal of Pharmaceutical Negative Results 13 (2022), 38-43. doi:10.47750/pnr.2022.13.02.006



MLA (The Modern Language Association) Style

, Sedighe J. Gandomani, Dhiya Altememy, Akram Alizadeh, Zeinab Tavakol, and Pegah Khosravian. "Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study." Journal of Pharmaceutical Negative Results 13.2 (2022), 38-43. Print. doi:10.47750/pnr.2022.13.02.006



APA (American Psychological Association) Style

, S. J. G., , . D. A., , . A. A., Tavakol, . Z. & Khosravian, . P. (2022) Improvement of rat cervicitis using medicinal smoke condensate of jennet feces: animal model set up and vaginal cream production; histopathological study. Journal of Pharmaceutical Negative Results, 13 (2), 38-43. doi:10.47750/pnr.2022.13.02.006