E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits

Haider F Al-Saedi, Uday Abdul-Reda Hussein, Mukhallad A Ramadhan.

Abstract
Background: Cardiotoxicity is a life-threatening adverse effect of adriamycin and limits its clinical uses.
Aim: This study is aimed to investigate the protective effect of pentoxifylline against cardiotoxicity induced by adriamycin.
Materials and Methods: Twenty-four healthy rabbits were equally divided into three groups and were distributed into control group, adriamycin group and pentoxifylline group. Both the first and second groups were received normal saline (2mL/kg IP.), while the third group received pentoxifylline (100 mg/kg IP.) for fourteen consecutive days. All animals (except animals of control group) were given adriamycin (5 mg/kg IP.) at the 1st, 5th,9th and 13th days of experiment for induction of cardiotoxicity. On the last day of the experiment, blood samples and heart tissues were collected from all animals for biochemical analysis and histopathological examination.
Results: Adriamycin induced cardiotoxicity manifested by a significant elevation of serum CK-MB and LDH levels, besides significant elevation in cardiac homogenate levels of MDA, TNF-α and IL-6 with a reduction in GSH level which was further confirmed by histological changes. Pentoxifylline significantly restoring the biochemical and histological abnormalities.
Conclusion: Pentoxifylline has a potent cardioprotective effect and can be used as an adjuvant therapy to abrogate cardiotoxicity of adriamycin and extend its clinical uses.

Key words: Cardiotoxicity; Adriamycin; Pentoxifylline; Rabbits; Cancer; Chemotherapy


 
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How to Cite this Article
Pubmed Style

HFA, Hussein UA, Ramadhan MA. Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. PNR. 2022; 13(2): 51-56. doi:10.47750/pnr.2022.13.02.008


Web Style

HFA, Hussein UA, Ramadhan MA. Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. https://www.pnrjournal.com/?mno=30535 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.008


AMA (American Medical Association) Style

HFA, Hussein UA, Ramadhan MA. Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. PNR. 2022; 13(2): 51-56. doi:10.47750/pnr.2022.13.02.008



Vancouver/ICMJE Style

HFA, Hussein UA, Ramadhan MA. Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. PNR. (2022), [cited August 11, 2022]; 13(2): 51-56. doi:10.47750/pnr.2022.13.02.008



Harvard Style

, H. F. A., Hussein, . U. A. & Ramadhan, . M. A. (2022) Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. PNR, 13 (2), 51-56. doi:10.47750/pnr.2022.13.02.008



Turabian Style

, Haider F Al-Saedi, Uday Abdul-Reda Hussein, and Mukhallad A Ramadhan. 2022. Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. Journal of Pharmaceutical Negative Results, 13 (2), 51-56. doi:10.47750/pnr.2022.13.02.008



Chicago Style

, Haider F Al-Saedi, Uday Abdul-Reda Hussein, and Mukhallad A Ramadhan. "Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits." Journal of Pharmaceutical Negative Results 13 (2022), 51-56. doi:10.47750/pnr.2022.13.02.008



MLA (The Modern Language Association) Style

, Haider F Al-Saedi, Uday Abdul-Reda Hussein, and Mukhallad A Ramadhan. "Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits." Journal of Pharmaceutical Negative Results 13.2 (2022), 51-56. Print. doi:10.47750/pnr.2022.13.02.008



APA (American Psychological Association) Style

, H. F. A., Hussein, . U. A. & Ramadhan, . M. A. (2022) Protective effects of pentoxifylline against adriamycin –induced cardiotoxicity in rabbits. Journal of Pharmaceutical Negative Results, 13 (2), 51-56. doi:10.47750/pnr.2022.13.02.008