Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol

Raied M. Shakir; Husam S. Jasim; Shaimaa A. Saoud; Dhuha F. Hussain; Khalid F. Ali

doi:10.47750/pnr.2022.13.02.009

Original Article

PNR. 2022; 13(2): 57-68

doi: 10.47750/pnr.2022.13.02.009

Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol

Raied M. Shakir, Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, Khalid F. Ali.

Abstract
Newly series of 6,6'-((2-(Aryl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(2-methoxy phenol) (3a-i) were synthesized from cyclization of 6,6'-((propane-1,3-diylbis (azanediyl)) bis(methylene)) bis(2-methoxyphenol) with several aryl aldehyde in the presence of acetic acid. The newly compounds characterized from their IR, NMR and EIMs spectra. The antioxidant capacity of these compounds screened by utilizing DPPH and FRAP assays. Compounds 3g and 3i exhibited significant antioxidant capability in both assays. Docking study for these compounds as a potential inhibitors of gyrase enzyme were carried out. Compound 3g exhibited significant inhibition with binding free energies (DG) higher than novobiocin. compounds 2, 3a, 3b, 3f exhibited prominent DG.

Key words: hydro pyrimidine, Antioxidant, DPPH, FRAP, multi phenols, gyrase

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How to Cite this Article

Pubmed Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. 2022; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009

Web Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. https://www.pnrjournal.com/?mno=28480 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.009

AMA (American Medical Association) Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. 2022; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009

Vancouver/ICMJE Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. (2022), [cited August 11, 2022]; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009

Harvard Style

Shakir, R. M., Jasim, . H. S., Saoud, . S. A., Hussain, . D. F. & Ali, . K. F. (2022) Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009

Turabian Style

Shakir, Raied M., Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, and Khalid F. Ali. 2022. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. Journal of Pharmaceutical Negative Results, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009

Chicago Style

Shakir, Raied M., Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, and Khalid F. Ali. "Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol." Journal of Pharmaceutical Negative Results 13 (2022), 57-68. doi:10.47750/pnr.2022.13.02.009

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Shakir, R. M., Jasim, . H. S., Saoud, . S. A., Hussain, . D. F. & Ali, . K. F. (2022) Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. Journal of Pharmaceutical Negative Results, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009

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