E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol

Raied M. Shakir, Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, Khalid F. Ali.

Abstract
Newly series of 6,6'-((2-(Aryl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(2-methoxy phenol) (3a-i) were synthesized from cyclization of 6,6'-((propane-1,3-diylbis (azanediyl)) bis(methylene)) bis(2-methoxyphenol) with several aryl aldehyde in the presence of acetic acid. The newly compounds characterized from their IR, NMR and EIMs spectra. The antioxidant capacity of these compounds screened by utilizing DPPH and FRAP assays. Compounds 3g and 3i exhibited significant antioxidant capability in both assays. Docking study for these compounds as a potential inhibitors of gyrase enzyme were carried out. Compound 3g exhibited significant inhibition with binding free energies (DG) higher than novobiocin. compounds 2, 3a, 3b, 3f exhibited prominent DG.

Key words: hydro pyrimidine, Antioxidant, DPPH, FRAP, multi phenols, gyrase


 
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How to Cite this Article
Pubmed Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. 2022; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009


Web Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. https://www.pnrjournal.com/?mno=28480 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.009


AMA (American Medical Association) Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. 2022; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009



Vancouver/ICMJE Style

Shakir RM, Jasim HS, Saoud SA, Hussain DF, Ali KF. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR. (2022), [cited August 11, 2022]; 13(2): 57-68. doi:10.47750/pnr.2022.13.02.009



Harvard Style

Shakir, R. M., Jasim, . H. S., Saoud, . S. A., Hussain, . D. F. & Ali, . K. F. (2022) Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. PNR, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009



Turabian Style

Shakir, Raied M., Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, and Khalid F. Ali. 2022. Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. Journal of Pharmaceutical Negative Results, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009



Chicago Style

Shakir, Raied M., Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, and Khalid F. Ali. "Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol." Journal of Pharmaceutical Negative Results 13 (2022), 57-68. doi:10.47750/pnr.2022.13.02.009



MLA (The Modern Language Association) Style

Shakir, Raied M., Husam S. Jasim, Shaimaa A. Saoud, Dhuha F. Hussain, and Khalid F. Ali. "Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol." Journal of Pharmaceutical Negative Results 13.2 (2022), 57-68. Print. doi:10.47750/pnr.2022.13.02.009



APA (American Psychological Association) Style

Shakir, R. M., Jasim, . H. S., Saoud, . S. A., Hussain, . D. F. & Ali, . K. F. (2022) Synthesis, Antioxidant, antibacterial and docking structure of new dihydro-pyrimidine derivatives containing multi phenol. Journal of Pharmaceutical Negative Results, 13 (2), 57-68. doi:10.47750/pnr.2022.13.02.009