E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals

Safaa H. Ganduh, Aseel M Aljeboree, Makarim A. Mahdi, Layth S. Jasim.

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  • Abstract
    This research has been based on the development of a fast, simple, sensitive, highly selective and accurate way for spectrophotometric estimation of metoclopramide hydrochloride (MCP HCl) drug in various pharmaceutical preparations. The method spectrophotometric depends on the diazotization of the primary amino group (MCP-HCl) with hydrochloric acid and (NaNO2) solution, also by interaction with a drug considered as a coupling agent is Phenylephrine hydrochloride (PH-HCl) in an alkaline medium. After completing the reaction, the orange color is formed, evidence of forming a stable azo dye for three hours and has a wavelength of 452 nm. Beers' law was applied in the range concentration of 1-10 mg/L, Correlation coefficient (r2=0.9995). Factors affecting absorbance and color stability were studied like Effect of sodium nitrite volume, Study of kind and acid concentration, Effect of Phenylephrine hydrochloride volume reagent: the optimum temperature was 25°C, the reaction time was 5 min., and the volume of Phenylephrine hydrochloride (PH-HCl) reagent was 1ml. The limit of detection (LOD) 1.21 x 10-2, the limit of quantification (LOQ) 4.063x10-2. Recoveries range 96.1%-104.1%. The way has been successfully useful to analyze the compound (MCP-HCl) in its pharmaceutical preparations (tablets, syrup).

    Key words: Colorimetric, Spectrophotometric, Determination, Phenylephrine hydrochloride Metoclopramide- HCl.


     
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    How to Cite this Article
    Pubmed Style

    Ganduh SH, AMA, Mahdi MA, Jasim LS. Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. PNR. 2021; 12(2): 44-48. doi:10.47750/pnr.2021.12.02.008


    Web Style

    Ganduh SH, AMA, Mahdi MA, Jasim LS. Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. https://www.pnrjournal.com/?mno=139750 [Access: May 21, 2022]. doi:10.47750/pnr.2021.12.02.008


    AMA (American Medical Association) Style

    Ganduh SH, AMA, Mahdi MA, Jasim LS. Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. PNR. 2021; 12(2): 44-48. doi:10.47750/pnr.2021.12.02.008



    Vancouver/ICMJE Style

    Ganduh SH, AMA, Mahdi MA, Jasim LS. Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. PNR. (2021), [cited May 21, 2022]; 12(2): 44-48. doi:10.47750/pnr.2021.12.02.008



    Harvard Style

    Ganduh, S. H., , . A. M. A., Mahdi, . M. A. & Jasim, . L. S. (2021) Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. PNR, 12 (2), 44-48. doi:10.47750/pnr.2021.12.02.008



    Turabian Style

    Ganduh, Safaa H., Aseel M Aljeboree, Makarim A. Mahdi, and Layth S. Jasim. 2021. Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. Journal of Pharmaceutical Negative Results, 12 (2), 44-48. doi:10.47750/pnr.2021.12.02.008



    Chicago Style

    Ganduh, Safaa H., Aseel M Aljeboree, Makarim A. Mahdi, and Layth S. Jasim. "Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals." Journal of Pharmaceutical Negative Results 12 (2021), 44-48. doi:10.47750/pnr.2021.12.02.008



    MLA (The Modern Language Association) Style

    Ganduh, Safaa H., Aseel M Aljeboree, Makarim A. Mahdi, and Layth S. Jasim. "Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals." Journal of Pharmaceutical Negative Results 12.2 (2021), 44-48. Print. doi:10.47750/pnr.2021.12.02.008



    APA (American Psychological Association) Style

    Ganduh, S. H., , . A. M. A., Mahdi, . M. A. & Jasim, . L. S. (2021) Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals. Journal of Pharmaceutical Negative Results, 12 (2), 44-48. doi:10.47750/pnr.2021.12.02.008