E-ISSN 2229-7723 | ISSN 0976-9234
 

Review Article 


Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan.

Abstract
Oxidative stress has been implicated in suicidal behavior and bipolar disorder (BD), respectively. However, the role of oxidative stress as a biomarker of suicidal behavior in BD remains inconclusive. This systematic review aims to determine the association between oxidative stress biomarkers and suicidal behavior among BD patients. All human studies from Scopus and Ovid Medline up until August 2017 on suicidal behavior, BD, and oxidative stress biomarkers were included according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of five studies met the eligibility criteria, of which 4 were case–control studies. Three studies identified at least one biomarker with significant association between suicidal acts and oxidative stress biomarkers (i.e., increased lipid peroxidation and NOS3 rs 1799983 TT genotype) in previous suicide attempt and increased deoxyribonucleic acid damage in suicide among sample populations with BD patients. No study reported conclusive associations between Ala-9 Val manganese superoxide dismutase or Pro 197 Leu glutathione peroxidase gene polymorphisms; or levels of nitric oxide metabolites, plasma total antioxidant potential, and malondialdehyde with suicidal acts among BD patients. Based on this systematic review, there is limited evidence of any association of the association between oxidative stress biomarkers and suicidal acts in BD patients. Definitive conclusions could not be ascertained due to lack of homogenous properly controlled and adequately powered studies. Future systematically well-designed and larger, prospective studies are warranted to clarify the role of oxidative stress pathways in the pathophysiology of suicidal behavior in BD.

Key words: Antioxidant, bipolar disorder, deoxyribonucleic acid damage, oxidative stress, suicidal behavior


 
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How to Cite this Article
Pubmed Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. 2019; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19


Web Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. https://www.pnrjournal.com/?mno=133428 [Access: May 21, 2022]. doi:10.4103/jpnr.JPNR_3_19


AMA (American Medical Association) Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. 2019; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19



Vancouver/ICMJE Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. (2019), [cited May 21, 2022]; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19



Harvard Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan (2019) Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR, 10 (1), 6-15. doi:10.4103/jpnr.JPNR_3_19



Turabian Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. 2019. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. Journal of Pharmaceutical Negative Results, 10 (1), 6-15. doi:10.4103/jpnr.JPNR_3_19



Chicago Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. "Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review." Journal of Pharmaceutical Negative Results 10 (2019), 6-15. doi:10.4103/jpnr.JPNR_3_19



MLA (The Modern Language Association) Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. "Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review." Journal of Pharmaceutical Negative Results 10.1 (2019), 6-15. Print. doi:10.4103/jpnr.JPNR_3_19



APA (American Psychological Association) Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan (2019) Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. Journal of Pharmaceutical Negative Results, 10 (1), 6-15. doi:10.4103/jpnr.JPNR_3_19