E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha.

Abstract
Background: Keeping in view the current scenario of increasing risk of dyslipidemia leading to coronary heart diseases in Indian population and dearth of conclusive evidences in support of homeopathic treatment of dyslipidemia, we intended to evaluate the efficacy of a frequently prescribed medicine Dioscorea villosa 6CH in comparison with placebo. Methods: In this prospective, double-blind, randomized, parallel arm, placebo-controlled trial, 100 patients diagnosed with dyslipidemia were randomized in 1:1 ratio to one of the two interventions – D. villosa 6CH or identical looking placebo in the mutual context of lifestyle modification advices. The outcome measure was the blood lipid profile – triglyceride, total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), very LDLc (VLDLc), and high-density lipoprotein cholesterol (HDLc), assessed at baseline and 2 months after intervention. Comparative analysis was conducted on intention-to-treat basis to detect group differences using SPSS. Results: The groups were comparable at baseline. After 2 months of intervention, pre–post comparison showed significant changes in triglyceride, TC, and VLDLc in the verum group and triglyceride, TC, and LDLc in the placebo group; however, the group differences were non-significant: triglyceride (P = 0.809), TC (P = 0.316), HDLc (P = 0.430), LDLc (P = 0.192), and VLDLc (P = 0.251). Per protocol analysis also revealed similar non-significant trends. Conclusion: D. villosa 6CH could not produce any differentiable effect from placebo in treatment of dyslipidemia. Trial registration: Clinical Trials Registry – India/2018/04/013511.

Key words: Dioscorea villosa, dyslipidemia, homeopathy, placebo, randomized controlled trial


 
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How to Cite this Article
Pubmed Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. pnr. 2020; 11(1): 59-64. doi:10.4103/jpnr.JPNR_13_19


Web Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. http://www.pnrjournal.com/?mno=133408 [Access: September 22, 2020]. doi:10.4103/jpnr.JPNR_13_19


AMA (American Medical Association) Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. pnr. 2020; 11(1): 59-64. doi:10.4103/jpnr.JPNR_13_19



Vancouver/ICMJE Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. pnr. (2020), [cited September 22, 2020]; 11(1): 59-64. doi:10.4103/jpnr.JPNR_13_19



Harvard Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha (2020) Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. pnr, 11 (1), 59-64. doi:10.4103/jpnr.JPNR_13_19



Turabian Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. 2020. Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. Journal of Pharmaceutical Negative Results, 11 (1), 59-64. doi:10.4103/jpnr.JPNR_13_19



Chicago Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. "Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial." Journal of Pharmaceutical Negative Results 11 (2020), 59-64. doi:10.4103/jpnr.JPNR_13_19



MLA (The Modern Language Association) Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha. "Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial." Journal of Pharmaceutical Negative Results 11.1 (2020), 59-64. Print. doi:10.4103/jpnr.JPNR_13_19



APA (American Psychological Association) Style

Kisor Kumar Naskar, Ompriya Mishra, Abhijit Chattopadhyay, Ashutosha Kumar, Aniruddha Banerjee, Laijun Nahar, Seeta Singh, Ritika Asthana, Jasleen Luthra, Mohammad Abdul Karim, Tirthankar Banerjee, S K Swaif Ali, Anamika Basu, Munmun Koley, Subhranil Saha (2020) Efficacy of Dioscorea villosa 6CH in treatment of dyslipidemia: A double-blind, randomized, placebo-controlled, clinical trial. Journal of Pharmaceutical Negative Results, 11 (1), 59-64. doi:10.4103/jpnr.JPNR_13_19