No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis

Thara Tunthanathip; Kantapong Mamueang; Nichapat Nilbupha; Chattarin Maliwan; Tanan Bejrananda

doi:10.4103/jpnr.JPNR_22_19

2022, Vol: 13, Issue: 1

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Original Article

PNR. 2020; 11(1): 1-8

doi: 10.4103/jpnr.JPNR_22_19

No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda.

Abstract
Objective: To systematically examine the prognostic significance of isocitrate dehydrogenase 1 (IDH1) mutations according to country region. Methods: We searched five electronic databases from inception to September 2019 for relevant studies. A meta-analysis was performed after evaluating which studies met the inclusion criteria. Thirty-seven were identified for this meta-analysis, comprising 5141 GBM patients. Results: The benefit of overall survival (OS) was the hazard ratio (HR), 0.67 (95% confidence interval [CI], 0.610.74). When subgroup analysis by country region, the pooled HR for the Eastern population studies was 1.15 (95% CI: 0.971.35) with no association between IDH1 mutation and OS of GBM, while IDH1 mutation still had a significant survival advantage in the Western population studies (HR: 0.51, 95% CI: 0.450.57). Conclusions: This study confirmed that IDH1 mutation is an independent prognostic factor for patients with GBM. However, a topographic relationship was observed in the results, and an association between this genetic mutation and prognosis should be explored in future studies.

Key words: Glioblastoma, isocitrate dehydrogenase 1, meta-analysis, survival, systematic review

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Pubmed Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. PNR. 2020; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19

Web Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. https://www.pnrjournal.com/?mno=133346 [Access: May 21, 2022]. doi:10.4103/jpnr.JPNR_22_19

AMA (American Medical Association) Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. PNR. 2020; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19

Vancouver/ICMJE Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. PNR. (2020), [cited May 21, 2022]; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19

Harvard Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda (2020) No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. PNR, 11 (1), 1-8. doi:10.4103/jpnr.JPNR_22_19

Turabian Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. 2020. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. Journal of Pharmaceutical Negative Results, 11 (1), 1-8. doi:10.4103/jpnr.JPNR_22_19

Chicago Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. "No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis." Journal of Pharmaceutical Negative Results 11 (2020), 1-8. doi:10.4103/jpnr.JPNR_22_19

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APA (American Psychological Association) Style

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