Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset

Viacheslav Yu. Pauls

2021, Vol: 12, Issue: 2

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Original Article

PNR. 2021; 12(2): 24-28

doi: 10.47750/pnr.2021.12.02.004

Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset

Viacheslav Yu. Pauls.

Abstract
The purpose of this paper is to study the redox status and biochemical parameters of T341P desminopathy in a heterozygous state. Most
of the studied indicators of oxidative stress increase when approaching the middle course of T341P desminopathy. In particular, malondialdehyde and 8-OH-deoxyguanosine increase by 1.2 and 2 times, respectively, and the content of glutathione and coenzyme Q10 increase
by 1.9 times. An increase in the level of uric acid in the blood of the proband was established up to 1.5 times, exceeding the upper reference
limits by 10 - 12%. With the progression of desminopathy, decreased functional activity of the kidneys occurs with a considerable reduction
in glomerular filtration. Five days before the death of the proband’s father suffering from desminopathy, serious changes were observed in
nitrogen metabolism. The data obtained complements the picture of pathological mechanisms impacting desminopathy.

Key words: Desminopathy, Myoglobin, Nitrogen metabolism, Redox status, Uric acid.

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Pubmed Style

Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004

Web Style

Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . http://www.pnrjournal.com/?mno=116535 [Access: January 12, 2022]. doi:10.47750/pnr.2021.12.02.004

AMA (American Medical Association) Style

Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004

Vancouver/ICMJE Style

Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . PNR. (2021), [cited January 12, 2022]; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004

Harvard Style

Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . PNR, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004

Turabian Style

Viacheslav Yu. Pauls. 2021. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004

Chicago Style

Viacheslav Yu. Pauls. "Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset ." Journal of Pharmaceutical Negative Results 12 (2021), 24-28. doi:10.47750/pnr.2021.12.02.004

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset . Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004

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