E-ISSN 2229-7723 | ISSN 0976-9234
 
2022, Vol: 13, Issue: 2
13/2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset

Viacheslav Yu. Pauls.

SUPPLEMENTARY FILES :

  • 219-1640339128-adt-1.pdf ()

    • Abstract
    The purpose of this paper is to study the redox status and biochemical parameters of T341P desminopathy in a heterozygous state. Most
    of the studied indicators of oxidative stress increase when approaching the middle course of T341P desminopathy. In particular, malondialdehyde and 8-OH-deoxyguanosine increase by 1.2 and 2 times, respectively, and the content of glutathione and coenzyme Q10 increase
    by 1.9 times. An increase in the level of uric acid in the blood of the proband was established up to 1.5 times, exceeding the upper reference
    limits by 10 - 12%. With the progression of desminopathy, decreased functional activity of the kidneys occurs with a considerable reduction
    in glomerular filtration. Five days before the death of the probandÂ’s father suffering from desminopathy, serious changes were observed in
    nitrogen metabolism. The data obtained complements the picture of pathological mechanisms impacting desminopathy.

    Key words: Desminopathy, Myoglobin, Nitrogen metabolism, Redox status, Uric acid.


    		 
    ARTICLE TOOLS
    Abstract
    PDF Fulltext
    How to cite this articleHow to cite this article
    Citation Tools
    Related Records
     Articles by Viacheslav Yu. Pauls
    on Google
    on Google Scholar


    How to Cite this Article
    Pubmed Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004

    Web Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. https://www.pnrjournal.com/?mno=116535 [Access: August 12, 2022]. doi:10.47750/pnr.2021.12.02.004

    AMA (American Medical Association) Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004


    Vancouver/ICMJE Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. (2021), [cited August 12, 2022]; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004


    Harvard Style

    Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004


    Turabian Style

    Viacheslav Yu. Pauls. 2021. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004


    Chicago Style

    Viacheslav Yu. Pauls. "Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset." Journal of Pharmaceutical Negative Results 12 (2021), 24-28. doi:10.47750/pnr.2021.12.02.004


    MLA (The Modern Language Association) Style

    Viacheslav Yu. Pauls. "Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset." Journal of Pharmaceutical Negative Results 12.2 (2021), 24-28. Print. doi:10.47750/pnr.2021.12.02.004


    APA (American Psychological Association) Style

    Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004


    Author Login Reviewer Login About Publisher Editorial Policies Peer Review Policy Editorial & Peer Review Process Author's Rights and Obligations Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights) Privacy Policy Publication Ethics and Publication Malpractice Statement Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information
    This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.
    The articles in Journal of Pharmaceutical Negative Results are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
    Copyright © 2022 Journal of Pharmaceutical Negative Results All Rights Reserved. Subject to change without notice from or liability to Journal of Pharmaceutical Negative Results.
    For best results, please use Internet Explorer or Google Chrome

    Contact Information


      ResearchTrentz

     Scientific Research Community 

    Contact US

    21, First Floor,ResearchTrentz (Registred Office)
                              Thamotharan Street,India

     Email : editorial@pnrjournal.com, Support : pnrjournal@gmail.com